Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PABPC1L contributors: mct/npt - updated : 09-01-2013
HGNC name poly(A) binding protein, cytoplasmic 1-like
HGNC id 15797
Location 20q13.12      Physical location : 43.538.702 - 43.567.962
Synonym name
  • polyadenylate-binding protein 1-like
  • chromosome 20 open reading frame 119
  • embryonic poly(A) binding protein
    • Synonym symbol(s) ePAB, PABC1, C20orf119, dJ1069P2.3, PABPC1L1, FLJ11840, FLJ30809, FLJ42053, PAPBL3
    DNA
    TYPE functioning gene
    STRUCTURE 29.26 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2129 - 619 - 2008 18716053
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiensmRNA
    Endocrinepancreas     Homo sapiensmRNA
     parathyroid   highly
     thyroid   highly
    Lymphoid/Immunethymus     Homo sapiensmRNA
    Reproductivefemale systemovary    Homo sapiensmRNA
     male systemtestis    Homo sapiensmRNA
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Xenopus laevis
    Reproductiveoocyte Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C domain of poly(A)-binding protein
    • HOMOLOGY
    interspecies ortholog to murine Epab (84 p100)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • plays potentially a central role in the regulation of maternal mRNA activation by preventing deadenylation and promoting translation
  • predominant poly(A) binding protein in immature (germinal vesicle) and mature (metaphase II) oocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PABPC1L and YBX1 associate with STAU2-containing mRNPs through RNAs
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS