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FLASH GENE
Symbol PABPC1 contributors: mct/ - updated : 08-12-2016
HGNC name poly(A) binding protein, cytoplasmic 1
HGNC id 8554
Location 8q22.3      Physical location : 101.715.143 - 101.734.315
Synonym name
  • poly(A)-binding protein, cytoplasmic 2
  • polyadenylate-binding protein 1
  • Synonym symbol(s) PABP1, PABPL1, PAB1, PABP, PABPC, PABPC2
    DNA
    TYPE functioning gene
    STRUCTURE 19.17 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure a cis-regulatory element composed of a cytidine residue at the cap site followed by an interrupted stretch ol pyrimidines (5' - TOP motif)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text 2848 bp with a splicing variant (38kDa)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2869 - 636 - 2007 17785442
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four RNA binding domains RRM1 to RRM4
  • a MLLE domain recruiting various regulatory proteins and translation factors to poly(A) mRNAs through binding of a conserved 12 AAs peptide motif called PAM2 (for PABP-interacting motif 2)
  • a C terminal proline-rich sequence (poly (A)-binding protein)
  • HOMOLOGY
    Homologene
    FAMILY
  • poly (A)-binding proteins family
  • CATEGORY RNA associated , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • distributed in polyribosomes and in translationally inactive messenger ribonucleoprotein particles
  • basic FUNCTION
  • involved in the regulation of translation initiation, mRNA stability, regulation of poly(A) tail length
  • stimulating translation termination
  • may potentially function in translational repression during spermatogenesis
  • cytoplasmic PABPC1 plays a crucial role in regulating both translation and stability of eukaryotic mRNA
  • cytosolic poly(A) binding protein PABPC1 involved in mitochondrial translation inhibition
  • co-ordinative roles for DDX3X, EIF4E and PABPC1 in integrating environmental stress with translational regulation
  • association of the translation factors polyadenylate-binding protein-1 (PABPC1) and EIF4G1 is essential for high-level expression of polyadenylated mRNAs
  • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text initiation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the eukaryotic translation initiation complex eIF4F with eIF4A, eIF4E, eIF4EBPs, MNK1
  • INTERACTION
    DNA
    RNA binds mRNA poly(A) tails and affects mRNA stability and translation, in some situations interact with other RNA regions in addition to the poly(A) tail
    small molecule
    protein
  • SCA2 (potential ligand of PABC1), PAIP1
  • major cytoplasmic RNA-binding protein
  • interacting with TOB1
  • EIF4G1-PABPC1 interaction has been implicated in enhancing the formation of 48 S and 80 S initiation complexes and ribosome recycling through mRNA circularization
  • PAIP1 act as a translational activator in 5 prime cap-dependent translation by interacting with PABPC1 and the initiation factors EIF4A and EIF3A
  • in addition to PPP2CA, IGBP1 interacts with UBR5 and PABPC1, suggesting its involvement in multiple steps in the MTOR pathway that leads to translation initiation and cell-cycle progression
  • GSPT1 mediates translation termination-coupled mRNA decay via interaction with a cytosolic poly(A)-binding protein (PABPC1)
  • EIF4G1 interacts with the RRM2 domain of PABPC1
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • ATXN2 binds directly to RNAs in a PABPC1-independent manner
  • conserved function of the PUM1, PUM2 RBD is to bind specific mRNAs, antagonize PABPC1 function, and promote deadenylation
  • interaction of BTG2 with the first RRM domain of PABPC1 is required for BTG2 to control cell proliferation
  • YTHDF3 cooperates with two cofactors, PABPC1 and EIF4G2, to promote FOXO3 translation by binding to the translation initiation region of FOXO3 mRNA
  • cell & other
    REGULATION
    Other translationally controlled through a cis-regulatory element
    methylated by arginine methyltransferase CARM1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Epab(-/-) female mice were infertile, and could not generate embryos or mature oocytes in vivo or in vitro