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FLASH GENE
Symbol PAAF1 contributors: npt - updated : 12-12-2005
HGNC name proteasomal ATPase-associated factor 1
HGNC id 25687
Location 11q13.4      Physical location : 73.588.032 - 73.638.779
Synonym name
  • WD repeat domain 71
  • protein G-16
  • Synonym symbol(s) PAAF, FLJ11848, WDR71, Rpn14
    DNA
    TYPE functioning gene
    STRUCTURE 50.00 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1585 42 392 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrinepancreas   highly
    Nervousbrain    
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • WD40 repeat domain
  • HOMOLOGY
    interspecies ortholog to chimpanzee LOC466705
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as a negative regulator of the proteasome by controling the assembly/disassembly of the proteasome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    rheumatoid arthritis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS