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FLASH GENE
Symbol PA2G4 contributors: mct - updated : 29-03-2008
HGNC name proliferation-associated 2G4, 38kDa
HGNC id 8550
Location 12q13.2      Physical location : 56.498.102 - 56.507.693
Synonym name
  • ErbB-3 binding protein
  • murine cell-cycle P38-2G4 homolog
  • Synonym symbol(s) P2G4, EBP1, p38-2G4
    DNA
    TYPE functioning gene
    STRUCTURE 9.59 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    RDH5 12q13-q14 retinol dehydrogenase 5 (11-cis and 9-cis) CD63 12q12-q13 CD63 antigen (melanoma 1 antigen) GDF11 12q12 growth differentiation factor 11 CIP29 12q13.13 cytokine induced protein 29 kDa ORMDL2 12q12 ORM1-like 2 (S. cerevisiae) DNAJ 12q13.13 DnaJ protein MMP19 12q14 matrix metalloproteinase 19 PYM 12q13.13 PYM protein DGKA 12q13.3 diacylglycerol kinase, alpha 80kDa SILV 12q13-q14 silver homolog (mouse) CDK2 12q13.3 cyclin-dependent kinase 2 SUOX RAB5B 12q13 RAB5B, member RAS oncogene family ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451 MBC2 12q13.13 hypothetical protein FLJ14451 MLC1SA 12q13.13 hypothetical protein FLJ14451 MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452 CS 12p11-qter citrate synthase TMEM4 12q15 transmembrane protein 4 USP52 12q13.2-q13.3 ubiquitin specific protease 52
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2643 42 394 only in the cytoplasm 2010 21098709
  • p42
  • specifically associates with NPM1 upon epidermal growth factor stimulation
  • - - - 48 - . localizes in both the cytoplasm and the nucleolus 2010 21098709
  • constantly binds NPM1
  • constitutively binds NPM1 in the nucleolus, for which B23 Lys263 sumoylation is indispensable
  • is transforming and promotes cell growth, clonogenicity, and invasion in human glioblastoma (GBM)
  • functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to TP53 downregulation
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pharynx   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine cell-cycle P38-2G4
    homolog to murine Plfap
    Homologene
    FAMILY
  • metallopeptidase family
  • peptidase m24c family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text confined to the nucleus during interphase and cytoplasmic from metaphase through to telophase
    basic FUNCTION
  • RNA-binding protein that is involved in growth regulation
  • involved in the control of cell replication
  • potent repressor of androgen receptor signaling
  • CELLULAR PROCESS cell cycle, division
    cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of cytoplasmic BCL-2 mRNP (messenger ribonucleoprotein particle) complexes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERBB3 binding protein (role in maintaining AR protein level)
  • interacting with AR (associated with the N-terminal domain of AR)
  • interaction with NPM1 (distinctively binds isoforms and regulates cell proliferation and survival through p42 and p48, respectively)
  • RNF20 acts as an E3 ubiquitin ligase for PA2G4 tumor suppressor and promotes its polyubiquitination and degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer (androgen-independent)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    therapeutic target for treatment of hormone refractory prostate cancer
    ANIMAL & CELL MODELS