basic FUNCTION
| catalyzing the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences |
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in collagens and other proteins |
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P3H2 is responsible for the hydroxylation of collagen IV, which has the highest 3-hydroxyproline content of all collagens (PMUID: 18487197) |
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tissue specific P3H1, P3H2, P3H3 gene expression in both fetal and adult tissues indicating a developmental role for prolyl 3-hydroxylase activity |
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role for P3H2 in post-translational modification of fibril-forming collagens |
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P3H1 preferentially 3-hydroxylates proline at a single site in collagen type I chains, whereas P3H2 is responsible for 3-hydroxylating multiple proline sites in collagen types I, II, IV, and V |
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is involved in the post-translational modification of fibrillar collagens |
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role for the Leprecans in the post-translational modification of collagens expressed in the stroma of the reproductive organs |