Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol P2RY8 contributors: mct - updated : 20-02-2010
HGNC name purinergic receptor P2Y, G-protein coupled, 8
HGNC id 15524
Location Xp22.33 or Yp11.3      Physical location : 1.531.465 - 1.656.037
Synonym symbol(s) P2Y8, MGC50878
DNA
TYPE functioning gene
STRUCTURE 74.57 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - DXYS60 - DXYS132 - DXYS136 - DXYS138 - DXYS140 - SLC25A6 - ASMTL - P2RY8 - DXYS144 - DXYS17 - DXYS146 - DXYS150 - PABX - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4240 - 359 - 2004 15466006
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   predominantly
 spleen   highly
Reproductivemale systemprostate   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion lymph, blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • high affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis
  • increased both the trans-activation activities of CREB and ELK1 as well as the transcriptional activities of the serum response element and enhancer-promoter fragments of the c-Fos and c-Myc genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    P2RY8-CRLF2 fusion in 7p100 of individuals with B-progenitor ALL (acute lymphoblastic leukemia) and 53p100 of individuals with ALL associated with Down syndrome
    tumoral fusion      
    to SOX5 has been reported in primary splenic follicular lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS