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FLASH GENE
Symbol P2RY6 contributors: mct - updated : 08-02-2013
HGNC name pyrimidinergic receptor P2Y, G-protein coupled, 6
HGNC id 8543
Location 11q13.5      Physical location : 72.975.569 - 73.009.656
Synonym symbol(s) P2Y6, MGC15335
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 34.09 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC390222 11 hypothetical gene supported by U08471; Z32564; NM_000804 FOLR1 11q13.3-q13.5 folate receptor 1 (adult) FOLR2 11q13.3-q13.5 folate receptor 2 (fetal) INPPL1 11q23 inositol polyphosphate phosphatase-like 1 PHOX2A 11q13.3-q13.4 paired-like (aristaless) homeobox 2a LOC220077 11q13.3 hypothetical gene supported by AF229166 LOC390223 11 similar to Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) SKD3 11q13.3 suppressor of potassium transport defect 3 ART2P 11q13 ADP-ribosyltransferase 2 pseudogene (RT6 antigen homolog, rat) PDE2A 11cen-q12.1 phosphodiesterase 2A, cGMP-stimulated CENTD2 11q13.3 centaurin, delta 2 STARD10 11q13 START domain containing 10 FLJ00012 11q13.3 hypothetical protein FLJ00012 KIAA0769 11q13.2 hypothetical protein FLJ00012 P2RY2 11q13.5-q14.1 purinergic receptor P2Y, G-protein coupled, 2 P2RY6 11q13.5 pyrimidinergic receptor P2Y, G-protein coupled, 6 ARHGEF17 11q13.3-q13.5 Rho guanine nucleotide exchange factor (GEF) 17 TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029
RNA
TRANSCRIPTS type messenger
text
  • four variants encoding the same protein
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 1555 36.4 328 - 1997 9412455
    4 splicing 1832 36.4 328 - 1997 9412455
  • differing in the 5' UTR compared to variant 1
  • 4 splicing 1700 36.4 328 - 1997 9412455
  • differing in the 5' UTR compared to variant 1
  • - splicing 2400 36 328 - 1997 9412455
  • differing in the 5' UTR and 3' UTR compared to variant 1
  • - - 2466 - 429 - 1997 9412455
    - - 2399 36.4 328 - 1997 9412455
    - - 2457 36.4 328 - 1997 9412455
    - - 2499 36.4 328 - 1997 9412455
    - - 2552 36.4 328 - 1997 9412455
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselaorta    Mus musculusAdult
    Digestiveintestine     Mus musculusAdult
    Endocrinepancreas     Homo sapiensAdult
     pancreas     Homo sapiensAdultmRNA
    Lymphoid/Immunespleen   highly Mus musculusAdult
     thymus   highly Mus musculusAdult
    Visualeyeretina    Rattus norvegicusAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Mus musculusAdult
    Nervousglia
    Visualamacrine cell Rattus norvegicusAdult
    Visualhorizontal association cell Rattus norvegicusAdult
    cell lineage osteoblastic and brain cell lines
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments
  • one rhodopsin-like GPCR superfamily motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus P2ry6
    ortholog to murine P2ry6
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
  • rhodopsin-like receptor
  • extracellular nucleotides, via P2RY2 and P2RY6, regulate neutrophil migration by controlling TLR2-induced IL8 release from human monocytes
  • important contribution of P2RY6 signaling in enhancing vascular inflammation during systemic LPS challenge
  • mediator of UVB-radiation-induced inflammatory responses in keratinocytes
  • stimulates bone resorption by osteoclasts, and may play an important role in the regulation of bone cell function
  • may be involved in retinal information processing in different ways, probably by regulating the release of transmitters and/or modulating the radial flow of visual signals and lateral interaction mediated by horizontal and amacrine cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by selectively activated by UDP
    Other predominantly responding to UDP
    UDP induces chemokine expression in microglia and astrocytes of the injured brain by activation of P2RY6
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    when neurons are damaged, and could function as a sensor for phagocytosis by sensing diffusible UDP signals
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    therapeutic target during systemic inflammatory responses
    ANIMAL & CELL MODELS
  • P2Y(6)R(-/-) mice have increased bone mineral content, cortical bone volume, and cortical thickness in the long bones and spine, whereas trabecular bone parameters were unaffected
  • P2ry6-deficient mice and have shown that these mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cell