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FLASH GENE

Symbol

P2RY6

contributors: mct - updated : 08-02-2013

HGNC name	pyrimidinergic receptor P2Y, G-protein coupled, 6
HGNC id	8543

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.5      Physical location : 72.975.569 - 73.009.656
Synonym symbol(s)	P2Y6, MGC15335

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	34.09 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	four variants encoding the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_176797 3 splicing 1555 NP_789767 36.4 328 - 1997 9412455 NM_176798 4 splicing 1832 NP_789768 36.4 328 - 1997 9412455 differing in the 5' UTR compared to variant 1 NM_176796 4 splicing 1700 NP_789766 36.4 328 - 1997 9412455 differing in the 5' UTR compared to variant 1 variant 4 - splicing 2400 36 328 - 1997 9412455 differing in the 5' UTR and 3' UTR compared to variant 1 NM_001277208 - - 2466 NP_001264137 - 429 - 1997 9412455 NM_001277207 - - 2399 NP_001264136 36.4 328 - 1997 9412455 NM_001277206 - - 2457 NP_001264135 36.4 328 - 1997 9412455 NM_001277205 - - 2499 NP_001264134 36.4 328 - 1997 9412455 NM_001277204 - - 2552 NP_001264133 36.4 328 - 1997 9412455

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel aorta       Mus musculus Adult Digestive intestine         Mus musculus Adult Endocrine pancreas         Homo sapiens Adult   pancreas         Homo sapiens Adult mRNA Lymphoid/Immune spleen       highly Mus musculus Adult   thymus       highly Mus musculus Adult Visual eye retina       Rattus norvegicus Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Mus musculus Adult Nervous glia Visual amacrine cell Rattus norvegicus Adult Visual horizontal association cell Rattus norvegicus Adult

cell lineage	osteoblastic and brain cell lines
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments
	one rhodopsin-like GPCR superfamily motif

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus P2ry6
	ortholog to murine P2ry6

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
	rhodopsin-like receptor
	extracellular nucleotides, via P2RY2 and P2RY6, regulate neutrophil migration by controlling TLR2-induced IL8 release from human monocytes
	important contribution of P2RY6 signaling in enhancing vascular inflammation during systemic LPS challenge
	mediator of UVB-radiation-induced inflammatory responses in keratinocytes
	stimulates bone resorption by osteoclasts, and may play an important role in the regulation of bone cell function
	may be involved in retinal information processing in different ways, probably by regulating the release of transmitters and/or modulating the radial flow of visual signals and lateral interaction mediated by horizontal and amacrine cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

selectively activated by UDP

Other	predominantly responding to UDP
	UDP induces chemokine expression in microglia and astrocytes of the injured brain by activation of P2RY6

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   when neurons are damaged, and could function as a sensor for phagocytosis by sensing diffusible UDP signals

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   therapeutic target during systemic inflammatory responses

ANIMAL & CELL MODELS

	P2Y(6)R(-/-) mice have increased bone mineral content, cortical bone volume, and cortical thickness in the long bones and spine, whereas trabecular bone parameters were unaffected
	P2ry6-deficient mice and have shown that these mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cell