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FLASH GENE
Symbol P2RY14 contributors: - updated : 20-05-2005
HGNC name purinergic receptor P2Y, G-protein coupled, 14
HGNC id 16442
Location 3q21-q25      Physical location : 150.929.904 - 150.996.230
Synonym name G protein-coupled receptor 105
Synonym symbol(s) KIAA0001, GPR105
DNA
TYPE functioning gene
STRUCTURE 66.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte
Lymphoid/Immunelymphocyte
Nervousglia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • seven hydrophobic domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Gpr105
    ortholog to rattus Vtr15-20
    Homologene
    FAMILY family 1 of G-protein coupled receptors
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • orphan receptor, playing a possible role in dendritic cell activation
  • playing an important role in peripheral and neuroimmune function in response to extracellular UDP-sugars
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by UDP-glucose
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS