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FLASH GENE
Symbol P2RY13 contributors: - updated : 15-09-2007
HGNC name purinergic receptor P2Y, G-protein coupled, 13
HGNC id 4537
Location 3q24      Physical location : 151.044.095 - 151.047.337
Synonym name G protein-coupled receptor 86
Synonym symbol(s) FKSG77, GPR94, P2Y13, SP174, GPR86, GPCR1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with GPR87 and P2RY12
STRUCTURE 3.00 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two variants encoding the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2858 38 333 - -
- splicing 2767 38 333 - -
  • differring in the 5' UTR compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveliver    
    Nervousbrain   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • three N-glycosylation sites
  • two protein kinase C sites
  • a protein kinase A site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Gpr86 / P2ry13
    Homologene
    FAMILY G protein coupled receptor 1 family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein, present on the membrane of hepatocytes
    basic FUNCTION
  • playing a role of orphan receptor
  • being a G(i)-coupled receptor displaying a high affinity for ADP
  • might play a role in hematopoiesis and the immune system
  • key regulator of hepatic high-density lipoprotein (HDL) endocytosis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ADP
  • protein
    cell & other
    REGULATION
    activated by ADP
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS