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FLASH GENE
Symbol OXTR contributors: mct/npt/pgu - updated : 09-06-2010
HGNC name oxytocin receptor
HGNC id 8529
Location 3p25.3      Physical location : 8.792.096 - 8.811.300
Synonym symbol(s) OT-R, OTR
DNA
TYPE functioning gene
STRUCTURE 19.21 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure a CpG island from 140 bp upstream to 2338 bp downstream of the transcription start site, methylated in the liver
MAPPING cloned Y linked N status confirmed
Physical map
LOC389092 3 LOC389092 LMCD1 3p26-p24 LIM and cysteine-rich domains 1 LOH3CR2A 3 loss of heterozygosity, 3, chromosomal region 2, gene A LOC51066 3p25.3 fls485 LOC391507 3 similar to seven transmembrane helix receptor CAV3 3p25 caveolin 3 OXTR 3p25 oxytocin receptor RAD18 3p25-p24 RAD18 homolog (S. cerevisiae) SRGAP2 3p25.3 SLIT-ROBO Rho GTPase activating protein 2 LOC391508 3 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) DKFZP434F091 3p25.3 DKFZP434F091 protein FLJ10707 3p25.3 hypothetical protein FLJ10707 LOC375323 3p25.3 lipoma HMGIC fusion partner-like protein 4 FLJ22405 3p26 hypothetical protein FLJ22405 LOC151835 3p25.3 copine family member BRPF1 3p26-p25 bromodomain and PHD finger containing, 1 OGG1 3p26.2 8-oxoguanine DNA glycosylase CAMK1 3p25.2 calcium/calmodulin-dependent protein kinase I TADA3L 3p25.3 transcriptional adaptor 3 (NGG1 homolog, yeast)-like ARPC4 3p25.3-p24.1 actin related protein 2/3 complex, subunit 4, 20kDa LOC389093 3 similar to RIKEN cDNA 4833441J24 DKFZP434B103 MGC29784 3p25.3 hypothetical protein MGC29784 CIDE-3 3p25.3 cell death activator CIDE-3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4361 - 389 - 1997 9433921
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 female systemuterus  highly
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   highly
Urinarykidney   highly
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in the developing male external genitalia
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three N-glycosylation sites in its extracellular N-terminal domain
  • seven transmembrane segments (7TM) receptor
  • E/DRY motif involved not only in receptor activation but also in the promiscuity of G protein coupling
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • oxytocin-oxytocin receptor system plays an important role in the uterus during parturition
  • might be involved in coordinating timely and appropriate proliferation and migration of the penile cells
  • exhibit promiscuous activity by coupling to both Galpha(q) and Galpha(i) G proteins to activate distinct signaling pathways
  • role of OXTR and the oxytocin signaling pathway in the etiology of autism
  • may be implicated in social cognition
  • central role of this receptor in the functionality of oxytocin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to autism spectrum disorders (not play a major role)
  • to variation of the prosocial disposition.
  • Variant & Polymorphism SNP
  • SNP (rs53576) known to predict prosocial tendencies is signaled through display behavior that leads to reliable observer inferences of the target prosociality
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS