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FLASH GENE
Symbol OXSR1 contributors: mct - updated : 22-10-2019
HGNC name oxidative-stress responsive 1
HGNC id 8508
Location 3p22.2      Physical location : 38.207.025 - 38.296.978
Synonym name serine/threonine-protein kinase OSR1
Synonym symbol(s) KIAA1101
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 89.95 kb     18 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located between the OCTL1 (604047) and MYD88 (602170) genes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 4525 58 527 in mouse : heart, spleen, liver, kidney, lung, testis, large and small intestines, stomach. in 293, Hela, PC3, BT20, HI299, SW480, 272I, Cos-1, C2C12 and 3T3 cell lines 2004 14707132
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyelens    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal kinase catalytic domain
  • a unique 92-amino-acid sequence called the conserved C-terminal (CCT) domain, having a specific docking site for the Arg-Phe-Xaa-Val (RFXV) sequence motifs located in the WNK1 and WNK4 activators
  • HOMOLOGY
    interspecies ortholog to murine Oxsr1
    intraspecies homolog to SOK1 (Ste20/oxidant stress response kinase-1)
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • distributed throughout HeLa cells
  • localized in cytoplasmic puncta and also in nuclei
  • basic FUNCTION
  • may play a role in regulating the actin cytoskeleton
  • key enzymes in a signaling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress
  • phosphorylate the N-terminal regulatory regions of cation-chloride-coupled cotransporters including SLC12A2, SLC12A1
  • regulates ion cotransporters, is activated in response to osmotic stress by WNK family members, and is largely associated with WNK1
  • STK39 is important for endothelial cell proliferation, whereas OXSR1 is required for HUVEC chemotaxis and invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text a serine/threonine protein kinase
    PATHWAY
    metabolism
    signaling
    signaling pathway that plays a key role in controlling the phosphorylation and activity of SLC12A3 (Richardson 2008)
    a component
  • WNK1-STK39/OXSR1 signalling pathway (Richardson 2008)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    protein
  • RELT family members physically interact with PLSCR1, and these interactions may regulate the phosphorylation of PLSCR1 by OXSR1
  • C-terminal WNK1 fragments can be phosphorylated by OXSR1, suggesting that OXSR1 catalyzes feedback phosphorylation of WNK1
  • both, STK39 and OXSR1 are negative regulators of SLC1A1 activity
  • STK39 and OXSR1 participate in the regulation of KCNQ1/KCNE1 protein abundance and activity
  • STK39 and OXSR1 are both stimulators of KCNJ2 activity, and they are presumably effective by enhancing channel insertion into the cell membrane
  • STK39 and OXSR1 entering cells through exosomes are preferentially expressed at the plasma membrane and the kinases in exosomes are functional and maintain SLC12A2 in a phosphorylated state
  • WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2
  • cell & other
    REGULATION
    activated by osmotic stresses, notably sorbitol and to a lesser extent NaCl
    WNK1
    Other oxidative-stress responsive 1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    STK39 and OXSR1 are promising drug targets for the treatment of hypertension, because inhibiting these enzymes would reduce SLC12A3 and SLC12A1 activity and thereby suppress renal salt re-absorption
    ANIMAL & CELL MODELS