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FLASH GENE
Symbol OXGR1 contributors: mct/npt - updated : 10-03-2010
HGNC name oxoglutarate (alpha-ketoglutarate) receptor 1
HGNC id 4531
Location 13q32.1      Physical location : 97.637.972 - 97.646.604
Synonym name
  • G protein-coupled receptor 80
  • G protein-coupled receptor 99
  • P2Y-like nucleotide receptor
  • P2Y purinoreceptor 2
  • seven transmembrane helix receptor
  • Synonym symbol(s) GPR80, GPR99, P2Y15, P2RY15, MGC119206, MGC119208
    DNA
    TYPE functioning gene
    STRUCTURE 8.63 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2285 - 337 - Lu (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratoryrespiratory tract    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Oxgr1
    homolog to rattus gpr80
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • transducing extracellular signals through heterotrimeric G proteins
  • having the ability to inhibit anchorage-independent growth in hepatoma cells (Lu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    receptor for the citric acid intermediate oxoglutarate ; cell surface receptor for AMP and adenosine
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    may be involved in renovascular hypertension
    tumoral     --low  
    by hypermethylation in hepatocellular carcinoma (Lu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS