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FLASH GENE
Symbol OVOL1 contributors: mct/npt/pgu - updated : 27-01-2016
HGNC name ovo-like 1(Drosophila)
HGNC id 8525
Location 11q13.1      Physical location : 65.554.528 - 65.564.683
Synonym name
  • ovo (Drosophila) homolog-like 1
  • putative transcription factor OVO-like 1
  • Synonym symbol(s) HOVO1
    DNA
    TYPE functioning gene
    STRUCTURE 10.16 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located located less than 200 kb proximal to the oncogene SEA
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3007 - 267 - 1997 9383297
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Reproductivefemale systemplacenta    Homo sapiens
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis  
    Muscularstriatumskeletal  
    cell lineage female germline specific
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, fetal kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal zinc fingers domains of the C2H2 type
  • HOMOLOGY
    interspecies homolog to Drosophila ovo
    ortholog to murine Ovol1
    homolog to C.elegans lin-48
    Homologene
    FAMILY
  • Ovo family of evolutionarily conserved zinc finger transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in hair formation and spermatogenesis
  • involved in the differentiation and/or maintenance of the urogenital system
  • negatively regulates its own expression by binding to and repressing the activity of its promoter
  • restricts its own expression by counteracting c-Myb activation and histone acetylation of the OVOL1 promoter
  • required for multiple developmental processes, including that of epidermis, hair follicles, kidney, and male germ cell differentiation
  • promotes the transition of cells from a proliferating, less-differentiated state to a quiescent more-differentiated state and may play an important role in regulating the balance between proliferation and differentiation of pancreatic cells
  • repressor of MYC transcription that regulates keratinocyte exit from the cell cycle and induction of differentiation
  • OVOL1, OVOL2 are gatekeepers of epithelial adhesion and differentiation by inhibiting progenitor-like traits and epithelial plasticity
  • regulates the transition from progenitor to differentiated trophoblast cell
  • important function of OVOL1 as a regulator of trophoblast progenitor cell fate during human trophoblast development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with NEUROG3 (negatively regulates transcription of OVOL1 in an E-box-dependent fashion)
  • directly bound by IRF6, and its expression is significantly altered in IRF6-depleted differentiating keratinocytes
  • OVOL1 and OVOL2, are critical inducers of MET in human cancers (pMID: 24124593)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to atopic dermatitis (AD)
    Variant & Polymorphism SNP
  • rs479844 upstream of OVOL1 associated with atopic dermatitis (AD)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS