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FLASH GENE
Symbol OTULINL contributors: mct - updated : 08-12-2021
HGNC name OTU deubiquitinase with linear linkage specificity like
HGNC id 25629
Location 5p15.2      Physical location : -
Synonym name
  • hypothetical protein FAM105A
  • hypothetical protein LOC54491
  • family with sequence similarity 105, member A
  • Synonym symbol(s) FLJ11127, NET20, FLJ43660, FAM105A
    DNA
    TYPE functioning gene
    STRUCTURE 34.40 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 7064 - 356 - 2019 31056421
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • FAM105 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • localizes to the ER membrane
  • basic FUNCTION
  • PPP1R1A, OTULINL, ENO2, and GNG5 are potential regulators of islet function
  • only putative pseudodeubiquitinase of the ovarian tumor protease (OTU domain) family
  • OTULINL functions through its ability to mediate protein-protein interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OTULIN interferes with endosome-to-plasma membrane trafficking and the OTULIN-related OTULINL (FAM105A) resides at the endoplasmic reticulum (ER)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS