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FLASH GENE

Symbol

OTUD6A

contributors: mct - updated : 14-12-2021

HGNC name	OTU deubiquitinase 6A
HGNC id	32312

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq13.1      Physical location : 69.282.340 - 69.284.029
Synonym symbol(s)	DUBA2, HSHIN6, FLJ25831
EC.number	3.4.19.12

DNA

TYPE	functioning gene
STRUCTURE	1.72 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_207320 1 - 1723 NP_997203 - 288 - 2021 33669244

EXPRESSION

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION

basic FUNCTION

promotes proliferation of cancer cells via regulating DNM1L stability and mitochondrial fission

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	expression of USP5 and OTUD6A may be affected by TP53
	OTUD6A is an Aurora-A-specific DUB
	OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in human patients with colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may serve as a therapeutic target in human cancers

ANIMAL & CELL MODELS