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FLASH GENE
Symbol OTUD5 contributors: mct - updated : 08-12-2021
HGNC name OTU deubiquitinase 5
HGNC id 25402
Corresponding disease
MCAND multiple congenital anomalies-neurodevelopmental syndrome
Location Xp11.23      Physical location : 48.779.304 - 48.815.648
Synonym symbol(s) DUBA, MCAND, MGC104871, DKFZp761A052
EC.number 3.4.19.12
DNA
TYPE functioning gene
STRUCTURE 38.76 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2407 - 349 - 2021 33110214
10 - 2662 - 566 - 2021 33110214
9 - 2888 - 566 - 2021 33110214
9 - 2903 - 571 - 2021 33110214
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
text
  • localizes to DNA double strand breaks (DSBs)
    • basic FUNCTION
  • localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis
  • OTUD5 is a new regulator of the DNA damage response
  • OTUD5 is indispensable for STING1-mediated antiviral and antitumor immunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • as a novel deubiquitinating enzyme for TP53, OTUD5 is required for the stabilization and the activation of a TP53 response
  • essential role for the PDCD5-OTUD5 network in TP53 activation
  • OTUD5 is a specific stabilizer of the UBR5 E3 ligase
  • OTUD5 regulates gene transcription and suppresses tumorigenesis by deubiquitinating TRIM25
  • OTUD5 interacts with STING1, cleaves its K48-linked polyubiquitin chains, and promotes its stability
  • is a novel positive regulator of the MTOR and CRTC2 signaling pathways (PMISD: 33110214)
    • cell & other
    REGULATION
    Phosphorylated by MTOR that directly phosphorylated OTUD5 and activated its DUB activity
    Other likely positive feedback loop between OTUD5 and MTOR signaling pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MCAND
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumor tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS