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FLASH GENE
Symbol OTUB2 contributors: mct - updated : 27-06-2022
HGNC name OTU domain, ubiquitin aldehyde binding 2
HGNC id 20351
Location 14q32.12      Physical location : 94.492.723 - 94.515.274
Synonym name
  • chromosome 14 open reading frame 137
  • ubiquitin-specific protease otubain 2
  • ubiquitin thioesterase OTUB2
  • otubain-2
  • Synonym symbol(s) OTB2, OTU2, MGC3102, FLJ21916, C14orf137
    EC.number 3.1.2.-/ 3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 22.55 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3873 - 234 - 2004 15014966
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • OTU subfamily of deubiquitinylases.
  • peptidase C65 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cysteine proteinase in the ubiquitin pathway, cleaving proteins precisely at the ubiquitin -protein bond
  • with OTUB1, are negative regulators of virus-triggered type I IFN induction
  • negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and TRAF6
  • both OTUB1 and OTUB2 display a catalytic triad characteristic of proteases but differ in their configuration and protonation states
  • OTUB1, OTUB2 are potential therapeutic targets against aging-related disorders
  • by activating the AKT1 signaling pathway, OTUB2 and KRT80 facilitated Gastric cancer proliferation
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus-triggered IRF3 and NF-kappaB activation, respectively
  • OTUB2 is a regulator of GLI2 protein degradation
  • OTUB2 may have effect on osteogenic differentiation by regulating HH signaling
  • OTUB2 is an essential modulator of YAP/TAZ
  • OTUB2 may serve as a vital driver in Gastric cancer tumorigenesis by enhancing KDM1A-mediated stem cell-like properties
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a novel prognostic marker in gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS