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Symbol OTUB2 contributors: mct - updated : 19-01-2011
HGNC name OTU domain, ubiquitin aldehyde binding 2
HGNC id 20351
Location 14q32.12      Physical location : 94.492.723 - 94.515.274
Synonym name
  • chromosome 14 open reading frame 137
  • ubiquitin-specific protease otubain 2
  • ubiquitin thioesterase OTUB2
  • otubain-2
  • Synonym symbol(s) OTB2, OTU2, MGC3102, FLJ21916, C14orf137
    EC.number 3.1.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 22.55 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3873 - 234 - 2004 15014966
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cysteine protease superfamily
  • peptidase C65 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • cysteine proteinase in the ubiquitin pathway, cleaving proteins precisely at the ubiquitin -protein bond
  • with OTUB1, are negative regulators of virus-triggered type I IFN induction
  • negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and TRAF6
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus-triggered IRF3 and NF-kappaB activation, respectively
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS