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FLASH GENE
Symbol OTP contributors: npt - updated : 06-11-2007
HGNC name orthopedia homeobox
HGNC id 8518
Location 5q13.3      Physical location : 76.924.537 - 76.934.522
Synonym name orthopedia homolog (Drosophila)
Synonym symbol(s) MGC3161
DNA
TYPE functioning gene
STRUCTURE 9.98 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
POLK 5q13 polymerase (DNA directed) kappa LOC391797 5 similar to hypothetical protein LOC348094 FLJ35779 5q13.3 hypothetical protein FLJ35779 LOC389304 5 hypothetical gene supported by AK125735 LOC391798 5 similar to importin alpha 1b LOC134356 5q13.3 similar to breast cancer associated protein BRAP1; bridging integrator-2 LOC134357 5q13.3 similar to mitochondrial aconitase LOC391799 5 similar to spermine synthase; spermidine aminopropyltransferase SV2C 5q13.3-q14.1 similar to spermine synthase; spermidine aminopropyltransferase LOC391800 5 similar to U1 snRNP-specific protein C IQGAP2 5q13.3 IQ motif containing GTPase activating protein 2 F2RL2 5q13 coagulation factor II (thrombin) receptor-like 2 F2R 5q13 coagulation factor II (thrombin) receptor F2RL1 5q13 coagulation factor II (thrombin) receptor-like 1 S100Z 5q14.1 S100Z protein CRHBP 5q11.2-q13.3 corticotropin releasing hormone binding protein HSU84971 5q14.1 vasculogenesis gene on 5q ZBED3 5q13.2 zinc finger, BED domain containing 3 LOC285711 5q14.1 hypothetical LOC285711 PDE8B 5q13.2 phosphodiesterase 8B ATQL1 5q14 antiquitin-like 1 FLJ10904 5q14.1 hypothetical protein FLJ10904 LOC391801 5 similar to ribosomal protein S2 LOC389305 5 similar to 60S ribosomal protein L7 OTP 5q13.3 orthopedia homolog (Drosophila) TBCA 5q13.3 tubulin-specific chaperone A ACTBP2 5q14.1 actin, beta pseudogene 2 AP3B1 5q12-q13.2 adaptor-related protein complex 3, beta 1 subunit SCAMP1 5q13.3-q14.1 secretory carrier membrane protein 1 LHFPL2 5q13.3 lipoma HMGIC fusion partner-like 2 ARSB 5q13 arylsulfatase B DMGDH 5q12.2-q12.3 arylsulfatase B BHMT2 5q13 betaine-homocysteine methyltransferase 2 BHMT 5q13.1-q15 betaine-homocysteine methyltransferase JMY 5q14.1 junction-mediating and regulatory protein HOMER1 5q25 homer homolog 1 (Drosophila) LOC133748 5q14.1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) FLJ38499 5q14.1 hypothetical protein FLJ38499 CMYA5 5q14.1 cardiomyopathy associated 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2702 35.1 325 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
 braindiencephalonamygdala  
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a helix-turn-helix DNA binding domain
  • a homeo domain
  • HOMOLOGY
    interspecies homolog to murine Otp
    homolog to Drosophila otp
    intraspecies homolog to orthopedia gene
    Homologene
    FAMILY
  • homeodomain (HD) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing key roles in the specification of cell fates
  • functioning during brain development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS