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FLASH GENE
Symbol OTOR contributors: mct/npt - updated : 14-06-2008
HGNC name otoraplin
HGNC id 8517
Location 20p12.1-p11.23      Physical location : 16.729.002 - 16.732.808
Synonym name
  • otoraplin, conserved cochlear gene
  • fibrocyte derived protein
  • melanoma inhibitory activity (MIA)-like
  • Synonym symbol(s) MIAL, FDP, MIAL1, MGC126737, MGC126739
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ENSAP 20p12.1 endosulfine alpha pseudogene PPIP11 20p12.1 peptidylprolyl isomerase (cyclophilin) pseudogene 11 C20orf23 20p11.23 chromosome 20 open reading frame 23 RPLP0P1 20p11.23 ribosomal protein, large, P0 pseudogene 1 RPL7AL3 20p11.23 ribosomal protein L7a-like 3 SNRPB2 20p12.2-p11.22 small nuclear ribonucleoprotein polypeptide B'' OTOR 20p12.1-p11.23 otoraplin PCSK2 20p11.2 proprotein convertase subtilisin/kexin type 2 BFSP1 20p11.23 beaded filament structural protein 1, filensin RPS27AP2 20p11.2 ribosomal protein S27a pseudogene 2 DSTN 20p11.23 destrin (actin depolymerizing factor) RRBP1 20p12-p11.2 ribosome binding protein 1 homolog 180kDa (dog) C20orf179 20 chromosome 20 open reading frame 179 SNX5 20pter-q11.23 sorting nexin 5 C20orf72 20p11.23 chromosome 20 open reading frame 72 PTMAP3 20p11.23 prothymosin, alpha pseudogene 3 (gene sequence 34) ZNF339 20pter-q11.23 zinc finger protein 339 RPL15P1 20p11.23 ribosomal protein L15 pseudogene 1 CSRP2BP 20p11.23 CSRP2 binding protein ZNF133 20p11.23-p11.22 zinc finger protein 133 (clone pHZ-13) C20orf12 20p11.23 chromosome 20 open reading frame 12 POLR3F 20p11.23 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa RBBP9 20p11.2 retinoblastoma binding protein 9 RPS19P1 20p11.23 ribosomal protein S19 pseudogene 1 SEC23B 20pter-p12.3 Sec23 homolog B (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1477 14.3 128 - Zhang (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea  
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text inner ear, brain, sensory epithelium of cochlea, vestibule
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal predicted signal sequence
  • four conserved cysteine residues
  • a SH3 domain, potential site for tyrosine O-sulfation
  • mono polymer homomer , dimer
    HOMOLOGY
    intraspecies homolog to CDRAP/MIA which is expressed by chondrocytes
    Homologene
    FAMILY
  • MIA/OTOR family
  • CATEGORY secretory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in cartilage development and maintenance, Turner-ear function
  • may contribute to inner-ear dysfunction in humans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS