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FLASH GENE
Symbol OTOGL contributors: mct/npt - updated : 05-12-2012
HGNC name otogelin-like
HGNC id 26901
Location 12q21.31      Physical location : -
Genatlas name otogelin-like protein
Synonym name
  • hypothetical protein LOC283310
  • chromosome 12 open reading frame 64
  • Synonym symbol(s) FLJ90579, MGC119410, C12orf64, DFNB84B
    DNA
    TYPE functioning gene
    STRUCTURE 158.29 kb     58 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    58 - 8083 - 2344 - 2012 23122586
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Digestiveintestinesmall intestineduodenum lowly Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
    Nervousbrain   moderately Homo sapiens
    Respiratorylung   lowly Homo sapiens
    Urinarykidney   moderately Homo sapiens
    Visualeyeretina  moderately Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • expressed in embryonic inner ear predominantly, and in fetal heart, lowly in skeletal muscle, kidney, spleen, and colon
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domains only (Schraders 2010)
  • N-terminal signal peptide of 22 AAs
  • a vWF and knot domains in the mature peptide
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein , unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • localized to the acellular membranes of the cochlea and the vestibular system and to a variety of inner ear cells located underneath these membranes
  • basic FUNCTION
  • normally involved in the production of the acellular structure, which may require relatively low of gene activity for the maintenance on the continuous basis
  • additional component of the inner ear acellular membranes that plays important functional roles in hearing
  • functions of OTOGL and OTOG are highly likely to be at least partially noncompensatory, as mutations in each of the corresponding genes can cause hearing loss
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS