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FLASH GENE
Symbol OTOA contributors: mct - updated : 10-10-2018
HGNC name otoancorin
HGNC id 16378
Corresponding disease
DFNB22 neurosensory deafness 22
Location 16p12.2      Physical location : 21.689.834 - 21.772.049
Synonym name
  • cancer/testis antigen 108
  • Synonym symbol(s) FLJ32773, MGC157747, MGC39813, CT108
    DNA
    TYPE functioning gene
    STRUCTURE 98.49 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390679 16 similar to sal-like 4 GP2 9q21.11-q21.2 glycoprotein 2 (zymogen granule membrane) UMOD 16p13.11 uromodulin (uromucoid, Tamm-Horsfall glycoprotein) LOC204474 16p13.11 hypothetical protein LOC204474 FLJ20581 16p13.11 hypothetical protein FLJ20581 LOC123876 16p13.11 hypothetical protein LOC123876 LOC348158 16p13.11 xenobiotic/medium-chain fatty acid:CoA ligase BUCS1 16p13;.1 butyryl Coenzyme A synthetase 1 LOC390680 16 similar to Hypothetical protein MGC56918 FLJ20274 16p13.11 hypothetical protein FLJ20274 SAH 16p13.11 SA hypertension-associated homolog (rat) MGC16943 16p13.11 similar to RIKEN cDNA 4933424N09 gene LOC81691 16p13.11 exonuclease NEF-sp MGC48972 16p13.11 hypothetical protein MGC48972 LOC57149 16p11.2 hypothetical protein A-211C6.1 FLJ23558 16p13.11-p12.3 hypothetical protein FLJ23558 DNAH3 16p12 dynein, axonemal, heavy polypeptide 3 LOC57146 16p12 promethin ZP2 16p12.2 zona pellucida glycoprotein 2 (sperm receptor) FLJ38819 16p12.3 hypothetical protein FLJ38819 CRYM 16p13.11-p12.3 crystallin, mu LOC388220 16 LOC388220 LOC92267 16p12.3 similar to FLJ12363 protein LOC388221 16 similar to nuclear pore complex interacting protein LOC388222 16 similar to MGC9515 protein LOC388223 16 similar to KIAA0220 IMAA 16p12 hLAT1-3TM LOC388224 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase DREV1 16p13-p12 DORA reverse strand protein 1 IGSF6 16p13-p12 immunoglobulin superfamily, member 6 OTOA 16p12.12 otoancorin LOC94431 16p12.3 similar to RNA polymerase I transcription factor RRN3 LOC390681 16 similar to RNA polymerase I transcription factor RRN3 MGC9515 16p12.3 hypothetical protein MGC9515 LOC390682 16 similar to PI-3-kinase-related kinase SMG-1 isoform 1; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase LOC342293 16p12.3 similar to hypothetical protein UQCRC2 16p12.2 ubiquinol-cytochrome c reductase core protein II MGC50721 16p12.3 hypothetical protein MGC50721 LOC146174 16p12.3 hypothetical protein LOC146174 LOC146177 16p12.3 hypothetical protein LOC146177 LOC390683 16 similar to NAD(P) dependent steroid dehydrogenase-like EEF2K 16p12.1-q12.2 similar to NAD(P) dependent steroid dehydrogenase-like RPC5 16p12.3 RNA polymerase III 80 kDa subunit RPC5 CDR2 16p12.2 cerebellar degeneration-related protein 2, 62kDa LOC390684 16 similar to RRN3 LOC283846 16p12.3 PI-3-kinase-related kinase SMG-1-like LOC388225 16 similar to MGC9515 protein HS3ST2 16p12 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 KIAA1203 16p12.3 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3624 126.7 1139 - 2012 23129639
    19 - 2718 89.8 815 - 2012 23129639
    24 - 3480 117.75 1060 - 2012 23129639
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative signal peptide
  • conserved cysteine residues involved in higher order protein structure via disulfide bound formation
  • eleven potential N glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Otoa
    intraspecies homolog to MPF
    Homologene
    FAMILY
  • stereocilin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text interface between the apical surface of sensory cells and their overlaping acellular gels
    basic FUNCTION
  • ensuring the attachment of the inner ear acellular gels to the apical surface of the underlying non sensory cells
  • OTOA is required for adhesion of the tectorial membrane (TM) to the spiral limbus and the TM, despite the structural abnormalities, retains its gross overall form, remaining in close proximity with the organ of Corti
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • spontaneous otoacoustic emissions (SOAE) in mice lacking Otoa predominate around 7 kHz, which is much lower than in WT animals