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FLASH GENE
Symbol OTOA contributors: mct - updated : 10-10-2018
HGNC name otoancorin
HGNC id 16378
Corresponding disease
DFNB22 neurosensory deafness 22
Location 16p12.2      Physical location : 21.689.834 - 21.772.049
Synonym name
  • cancer/testis antigen 108
  • Synonym symbol(s) FLJ32773, MGC157747, MGC39813, CT108
    DNA
    TYPE functioning gene
    STRUCTURE 98.49 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3624 126.7 1139 - 2012 23129639
    19 - 2718 89.8 815 - 2012 23129639
    24 - 3480 117.75 1060 - 2012 23129639
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative signal peptide
  • conserved cysteine residues involved in higher order protein structure via disulfide bound formation
  • eleven potential N glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Otoa
    intraspecies homolog to MPF
    Homologene
    FAMILY
  • stereocilin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text interface between the apical surface of sensory cells and their overlaping acellular gels
    basic FUNCTION
  • ensuring the attachment of the inner ear acellular gels to the apical surface of the underlying non sensory cells
  • OTOA is required for adhesion of the tectorial membrane (TM) to the spiral limbus and the TM, despite the structural abnormalities, retains its gross overall form, remaining in close proximity with the organ of Corti
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • spontaneous otoacoustic emissions (SOAE) in mice lacking Otoa predominate around 7 kHz, which is much lower than in WT animals