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FLASH GENE
Symbol OSTN contributors: mct/npt - updated : 18-12-2009
HGNC name osteocrin
HGNC id 29961
Location 3q28      Physical location : 190.930.321 - 190.967.908
Synonym name musclin
Synonym symbol(s) musclin
DNA
TYPE functioning gene
STRUCTURE 37.59 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 402 - 133 - Moffatt (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period neonatal
Text expression peaking just after birth and decreasing markedly with age
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NH(2)-terminal 30-amino acid signal sequence
  • a region homologous to natriuretic peptide family
  • KKKR, a putative serine protease cleavage site, similar to the natriuretic peptide family
  • HOMOLOGY
    interspecies homolog to murine Ostn
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a soluble osteoblast regulator
  • skeletal muscle-derived secretory factor playing a physiological in glucose metabolism
  • plays a role in the resistance of fast-glycolytic myofibers to the insulin-stimulated glucose uptake
  • playing a role as a specific NPR3 ligand capable of modulating local levels of C natriuretic peptide and its effects on skeletal development
  • naturally occurring ligand of the NPR3 clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR3, thus locally elevating levels of C-type natriuretic peptide (Moffatt 2007)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • naturally occurring ligand of the natriuretic peptide receptor-C (NPR3) clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR3, thus locally elevating levels of C-type natriuretic peptide
  • could interact with the natriuretic peptide (NP) receptors, thereby modulating NP actions on the skeleton and binds specifically and saturably to the NP peptide receptor-C (NPR3 receptor) (Moffatt 2007)
  • cell & other
    REGULATION
    repressed by FOXO1 (which should explain insulin-mediated upregulation of this gene in muscle cells )
    Other regulated by vitamin D
    regulated by nutritional changes, and by nutritional status (insulin is one of the factors implicated in the mediation of the regulation of musclin by nutritional status )
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS