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FLASH GENE

Symbol

OSMR

contributors: mct - updated : 11-03-2020

HGNC name	oncostatin M receptor
HGNC id	8507

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FPLCA familial primary localized cutaneous amyloidosis
Location	5p13.1      Physical location : 38.845.959 - 38.935.742
Synonym name	IL-31R subunit beta
	interleukin-31 receptor subunit beta
Synonym symbol(s)	OSMRB, MGC150626, MGC150627, MGC75127, IL-31R-beta, IL-31RBB, OSMRbeta, PLCA1

DNA

TYPE	functioning gene
STRUCTURE	99.72 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003999 18 - 5526 NP_003990 - 979 - 1998 9617575 NM_001323507 12 - 2234 NP_001310436 - 581 - 1998 9617575 NM_001168355 7 - 1825 NP_001161827 - 342 - 1998 9617575 NM_001323504 7 - 1945 NP_001310433 - 342 - 1998 9617575 NM_001323506 18 - 5268 NP_001310435 - 980 - 1998 9617575 NM_001323505 18 - 5265 NP_001310434 - 979 - 1998 9617575

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine pancreas         Respiratory respiratory tract larynx     highly   respiratory tract trachea     highly Skeleton appendicular skeleton joint synovia

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage
cell lines	malignant ovarian epithelial cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four extracellular fibronectin type III-like (FNIII) domains, regions critical for receptor dimerization and function
	a WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding
	a box 1 motif is required for JAK interaction and/or activation

HOMOLOGY

Homologene

FAMILY

IL6 family of cytokines

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	play a role in signal transduction (Scotto 2008)
	OSMR may act as a tumour suppressor in colorectal carcinoma and OSMR methylation may play an important role in non-invasive colorectal cancer
	adipocyte OSM&
	8315;OSMR signaling plays a role in adipose tissue CXCL12 production and may mitigate its effects on adipose tissue homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of OSM receptor complex (a heterodimer of GP130 or IL6ST and OSMR)
	part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family
	OSM and interleukin-31 (IL31) are two cytokines belonging to the IL6 family which share a common signaling receptor subunit, OSMR

INTERACTION

DNA

RNA

small molecule

protein	OSM is neuroprotective by recruiting OSMR in the setting of ischemic stroke
	SMARCA4 and STAT3 coordinately regulate gene clustering and up-regulate GFAP and OSMR transcription
	OSMR activates a non-redundant signaling pathway by recruitment of the adapter SHC1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FPLCA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of chronic autoimmune urticaria (CAU) tumoral     --over   in advanced cervical squamous cell carcinoma (SCC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a biomarker candidate gene to predict prognosis of bladder cancer
Therapy target

ANIMAL & CELL MODELS

mice, lacking the OSM receptor (Osmr) in adipocytes (OsmrFKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance