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FLASH GENE
Symbol OSM contributors: mct - updated : 08-09-2015
HGNC name oncostatin M
HGNC id 8506
Location 22q12.2      Physical location : 30.658.820 - 30.662.840
Synonym symbol(s) MGC20461
DNA
TYPE functioning gene
STRUCTURE 4.02 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D22S1 - EWSR1 - LIF - OSM - D22S268 - D22S15 - qter
Authors Rose (93),Giovannini (93)
Text see EWSR1
Physical map
RFPL1 22q12.2 ret finger protein-like 1 NEFH 22q12.2 neurofilament, heavy polypeptide 200kDa C22orf19 22q12 chromosome 22 open reading frame 19 NIPSNAP1 22q12.2 nipsnap homolog 1 (C. elegans) NF2 22q12.2 neurofibromin 2 (bilateral acoustic neuroma) CABP7 22q12.2 calcium binding protein 7 LOC55954 22cen-q12.3 hypothetical protein LOC55954 HSPC051 22cen-q12.3 ubiquinol-cytochrome c reductase complex (7.2 kD) ASC1p100 22q12.1 ASC-1 complex subunit P100 MTMR3 22q12.2 myotubularin related protein 3 LOC391326 22 similar to h2-calponin MGC26710 22q12.2 hypothetical protein MGC26710 LIF 22q12.2 leukemia inhibitory factor (cholinergic differentiation factor) OSM 22q12.2 oncostatin M TBC1D10 22q12.1-qter TBC1 domain family, member 10 SF3A1 22q12.1 splicing factor 3a, subunit 1, 120kDa LOC388891 22 similar to hypothetical protein 4930562D19 LOC200312 22q12.2 similar to RIKEN cDNA 0610009J22 SEC14L2 22q12.2 SEC14-like 2 (S. cerevisiae) HSPC242 22q hypothetical protein HSPC242 LOC391327 22 similar to solute carrier family 39 (zinc transporter), member 1; zinc-iron regulated transporter-like gene; solute carrier family 39 (zinc transporter), member 3; zinc/iron regulated transporter-like SEC14L3 22q12.2 SEC14-like 3 (S. cerevisiae) LOC376844 SEC14L4 22q12.1 SEC14-like 4 (S. cerevisiae) PTPNS1L 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like CST 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like PES1 22q12.2 pescadillo homolog 1, containing BRCT domain (zebrafish) TCN2 22q12.2 transcobalamin II; macrocytic anemia SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1880 - 252 - 2007 17881458
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Reproductivefemale systemovary   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • LIF/OSM family
  • gp130 cytokine family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • growth regulator which inhibits the proliferation of a number of tumor cell lines
  • inducing growth arrest and differentiation of osteoblastic cells into glial-like/osteocytic cells
  • could positively regulate the synthesis of its own soluble receptor in tumor cells
  • induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue
  • implicated in embryonic development, differentiation, inflammation, and regeneration of liver and bone (Song 2007)
  • promotes osteogenesis and suppresses adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (Song 2007)
  • potent inducer of SOCS3 in astrocytes
  • OSM-induced activation of STAT3 and the ERK1/2 and JNK pathways are critical for astrocytic expression of SOCS3, which provides for feedback inhibition of cytokine-induced inflammatory responses in the CNS)
  • may play a role in innate immunity and in acquired immunity by enhancing DCs maturation and promoting Th1 immune responses (Jung 2010)
  • major mediator of cardiomyocyte dedifferentiation and remodeling during acute myocardial infarction (MI) and in chronic dilated cardiomyopathy (DCM)
  • is a potent inhibitor of TGFB1-induced CTGF expression in human proximal tubular cells (PTC)
  • is a cytokine from the IL6 family that modulates proliferation and differentiation in numerous cells
  • role for OSM in promoting plaque angiogenesis
  • OSM produced from immune cells in white adipose tissue (WAT) acts in a paracrine manner on adipocytes to promote a proinflammatory phenotype in adipose tissue
  • OSM and interleukin-31 (IL31) are two cytokines belonging to the IL6 family which share a common signaling receptor subunit, OSMR
  • OSM is neuroprotective by recruiting OSMR in the setting of ischemic stroke
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYC is an important molecular switch that alters the cellular response to OSM-mediated signaling from tumor suppressive to tumor promoting (pMID: 21975934)
  • OSM-mediated inhibition of TGFB1-induced CTGF mRNA expression depends on STAT3
  • promotes mesenchymal stem cell-stimulated tumor growth through a paracrine mechanism involving periostin and TGFBI
  • promotes STAT3-dependent intestinal epithelial cell proliferation and wound healing
  • stimulate angiogenesis by upregulating VEGFA and FGF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in inflammatory bowel disease (IBD), OSM upregulation may modulate a barrier-protective host response in intestinal inflammation
    constitutional     --over  
    in obesity/type 2 diabetes mellitus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    may represent a promising drug candidate for stroke treatment
    cardiovascular  
    could be a novel therapeutic target for myocardial infarction (MI)
    ANIMAL & CELL MODELS