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FLASH GENE
Symbol OSBPL8 contributors: npt/mct/pgu - updated : 12-06-2010
HGNC name oxysterol binding protein-like 8
HGNC id 16396
Location 12q21.2      Physical location : 76.745.577 - 76.953.589
Synonym name
  • oxysterol-binding protein-related protein 8
  • OSBP-related protein 8
  • Synonym symbol(s) KIAA1451, OSBP10, ORP8, MST120, MSTP120, DKFZp686A11164, MGC126578, MGC133203
    DNA
    TYPE functioning gene
    STRUCTURE 208.01 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 7213 - 847 - 2001 11735225
    24 - 7259 - 889 - 2001 11735225
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal pleckstrin homology PH domain
  • a highly conserved OSBP-type sterol binding domain in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • oxysterol binding protein (OSBP) family
  • family of oxysterol-binding protein-related proteins (ORP)
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • localized in the endoplasmic reticulum (ER) via its C-terminal transmembrane span and binds 25-hydroxycholesterol, identifying it as a new ER oxysterol-binding protein
  • co-localization of OSBPL8 and NUP62 at the nuclear envelope
  • basic FUNCTION
  • negative regulator of ABCA1 expression and macrophage cholesterol efflux
  • modulate the development of atherosclerosis
  • endoplasmic reticulum oxysterol-binding protein implicated in cellular lipid homeostasis
  • has the capacity to modulate lipid homeostasis and SREBF activity, probably through an indirect mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP62 is an interaction partner of OSBPL8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS