Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol OSBPL8 contributors: npt/mct/pgu - updated : 12-06-2010
HGNC name oxysterol binding protein-like 8
HGNC id 16396
Location 12q21.2      Physical location : 76.745.577 - 76.953.589
Synonym name
  • oxysterol-binding protein-related protein 8
  • OSBP-related protein 8
  • Synonym symbol(s) KIAA1451, OSBP10, ORP8, MST120, MSTP120, DKFZp686A11164, MGC126578, MGC133203
    DNA
    TYPE functioning gene
    STRUCTURE 208.01 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TRHDE 12q15-q21 Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme (TRHDE), mRNA. VENTX2P3 12q15 VENT-like homeobox 2 pseudogene 3 LOC387869 12 LOC387869 LOC390343 12 similar to microtubule-associated proteins 1A/1B light chain 3 KCNC2 19q13.4 potassium voltage-gated channel, Shaw-related subfamily, member 2 CAPS2 12q21.1 calcyphosphine 2 MGC26856 12q21.1 hypothetical protein MGC26856 MGC39497 12q21.1 hypothetical protein MGC39497 GLIPR1 12q21.1 GLI pathogenesis-related 1 (glioma) HRB2 12q21.1 HIV-1 rev binding protein 2 LOC390344 12 similar to 6-phosphogluconate dehydrogenase, decarboxylating LOC390345 12 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) PHLDA1 12q15 pleckstrin homology-like domain, family A, member 1 NAP1L1 12q15 nucleosome assembly protein 1-like 1 LOC121071 12q21.1 similar to NOGO-interacting mitochondrial protein FLJ23560 12q21.1 hypothetical protein FLJ23560 OSBPL8 12q14 oxysterol binding protein-like 8 LOC123031 12q21.1 similar to 60S ribosomal protein L21 HIP14 12q14-q15 similar to 60S ribosomal protein L21 CSRP2 12q21.1 cysteine and glycine-rich protein 2 LOC390346 12 similar to Ran-specific GTPase-activating protein (Ran binding protein 1) (RanBP1) E2F7 12q21.1 E2F transcription factor 7 NAV3 12q21.1 neuron navigator 3 MRPL11P3 12q21.2 neuron navigator 3 LOC390347 12 similar to ras related v-ral simian leukemia viral oncogene homolog A SYT1 12q15-q21 synaptotagmin I LOC338756 12q21.2 similar to hypothetical protein PAWR 12q21.2-q21.32 PRKC, apoptosis, WT1, regulator PPP1R12A 12q15-q21 protein phosphatase 1, regulatory (inhibitor) subunit 12A LOC120872 12q21.2 similar to ribosomal protein L7 LOC283308 12q21.2 similar to 60S ribosomal protein L26 FLJ90579 12q21.2 hypothetical protein FLJ90579 LOC387870 12 similar to protein tyrosine phosphatase, receptor type, Q isoform 1 precursor; glomerular mesangial cell receptor protein-tyrosine phosphatase PTPRQ 12q21.2 protein tyrosine phosphatase, receptor type, Q
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 7213 - 847 - 2001 11735225
    24 - 7259 - 889 - 2001 11735225
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal pleckstrin homology PH domain
  • a highly conserved OSBP-type sterol binding domain in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • oxysterol binding protein (OSBP) family
  • family of oxysterol-binding protein-related proteins (ORP)
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • localized in the endoplasmic reticulum (ER) via its C-terminal transmembrane span and binds 25-hydroxycholesterol, identifying it as a new ER oxysterol-binding protein
  • co-localization of OSBPL8 and NUP62 at the nuclear envelope
  • basic FUNCTION
  • negative regulator of ABCA1 expression and macrophage cholesterol efflux
  • modulate the development of atherosclerosis
  • endoplasmic reticulum oxysterol-binding protein implicated in cellular lipid homeostasis
  • has the capacity to modulate lipid homeostasis and SREBF activity, probably through an indirect mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP62 is an interaction partner of OSBPL8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS