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FLASH GENE
Symbol OSBPL6 contributors: - updated : 04-04-2007
HGNC name oxysterol binding protein-like 6
HGNC id 16388
Location 2q31-q32.1      Physical location : 179.059.373 - 179.260.873
Synonym name OSBP-related protein 6
Synonym symbol(s) ORP6, FLJ36583, MGC59642
DNA
TYPE anonymous DNA segment
STRUCTURE 201.00 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3771 106.3 934 - Laitinen
skeletal muscle
- - 3548 - 938 lowly in brain Laitinen
- - - 4000 - - skeletal muscle Laitinen
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonepithalamuspineal glandhighly
 nervecranial nerve  highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal pleckstrin homology PH domain
  • a highly conserved OSBP type sterol binding domain in the C terminus
  • mono polymer homomer , dimer , trimer
    HOMOLOGY
    Homologene
    FAMILY oxysterol binding protein family of intracellular lipid receptors
    CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be playing a role in the regulation of sterol metabolism
  • binding a range of oxysterols
  • putative role in communication between the ER and the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text lipid transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • cholesterol metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to premature coronary artery disease in the absence of hypercholesterolemia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS