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FLASH GENE
Symbol OSBP2 contributors: mct - updated : 22-02-2008
HGNC name oxysterol binding protein 2
HGNC id 8504
Location 22q12.2      Physical location : 31.090.792 - 31.303.811
Synonym name
  • oxysterol binding protein-like 1
  • OSBP-related protein 4
  • oxysterol binding protein-related protein 4
    • Synonym symbol(s) ORP-4, OSBPL1, KIAA1664, ORP4, OSBPL4
    DNA
    TYPE functioning gene
    STRUCTURE 213.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4349 - 916 - Wyles (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Reproductivemale systemtestis  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal pleckstrin homology PH domain
  • a highly conserved OSBP-type sterol binding domain in the C terminus, that binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network
    • HOMOLOGY
    Homologene
    FAMILY oxysterol binding protein family
    CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putatively involved in the regulation of cholesterol metabolism
  • implicated in sterol-transport and/or sensing via binding to protein partners
  • could be involved in the maintenance of the undifferentiated state necessary for leukemogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS