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FLASH GENE
Symbol OS9 contributors: mct/npt - updated : 26-09-2009
HGNC name osteosarcoma amplified 9, endoplasmic reticulum lectin
HGNC id 16994
Location 12q14.1      Physical location : 58.087.737 - 58.115.338
Synonym name
  • homogeneously staining-region encoded sequence OS9
  • erlectin 2
  • amplified in osteosarcoma
  • Synonym symbol(s) OS-9, ERLEC2
    DNA
    TYPE functioning gene
    STRUCTURE 27.45 kb     15 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see MDM2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 2869 75.6 667 - Kimura, Bernasconi (2008)
    also called OS-9-1
    - splicing 2730 69 612 - Kimura, Bernasconi (2008)
  • also called OS-9-2
  • lacking an alternate in-frame exon compared to variant 1
  • 14 splicing 2685 - 597 - Kimura, Bernasconi (2008)
  • also called OS-9-3
  • using an alternate in-frame splice site in one exon compared to variant 1
  • lacking another in-frame exon compared to variant 1
  • 15 splicing 2824 - 652 - Kimura, Bernasconi (2008)
  • using an alternate in-frame splice site in the 3' coding region compared to variant 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   moderately
    Lymphoid/Immunespleen   moderately
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscular    
    cell lineage
    cell lines from an osteosarcoma-cell line
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved mannose 6-phosphate receptor homology (MRH) domains, binding to N-glycans lacking the C branch terminal mannose residues
  • lectin domain required to enhance the degradation of misfolded glycoproteins (Hosokawa 2009)
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Os-9
    Homologene
    FAMILY
  • OS-9 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text soluble fraction
    basic FUNCTION
  • may playing a role in cell viability
  • may playing a role in the ER-associated degradation of misfolded glycoproteins
  • plays a role as an auxiliary ER protein for select classes of membrane cargo proteins
  • having a lectin activity required for glycoprotein ERAD (Hosokawa 2009)
  • critically involved in the modulation of ER-to-Golgi transport of TM7SF4 in response to TLR triggering, suggesting a novel role for OS9 in myeloid differentiation and cell fusion (Jansen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the hypoxia-inducible factor 1 (HIF-1)
  • interacting with TRPV4 (TRPV4-binding protein)
  • interacting with SEL1L via its conserved mannose 6-phosphate receptor homology (MRH) domains
  • associated with HSP90B1
  • physically interacts with TM7SF4 (both proteins colocalize in the endoplasmic reticulum in various cell lines, including immature dendritic cells) (Jansen 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in osteosarcomas
    tumoral   amplification    
    coamplified with CDK4, PRIM1, SAS in osteosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS