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FLASH GENE

Symbol

OS9

contributors: mct/npt - updated : 26-09-2009

HGNC name	osteosarcoma amplified 9, endoplasmic reticulum lectin
HGNC id	16994

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q14.1      Physical location : 58.087.737 - 58.115.338
Synonym name	homogeneously staining-region encoded sequence OS9
	erlectin 2
	amplified in osteosarcoma
Synonym symbol(s)	OS-9, ERLEC2

DNA

TYPE	functioning gene
STRUCTURE	27.45 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see MDM2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006812 15 splicing 2869 NP_006803 75.6 667 - Kimura, Bernasconi (2008) also called OS-9-1 NM_001017956 - splicing 2730 NP_001017956 69 612 - Kimura, Bernasconi (2008) also called OS-9-2 lacking an alternate in-frame exon compared to variant 1 NM_001017957 14 splicing 2685 NP_001017957 - 597 - Kimura, Bernasconi (2008) also called OS-9-3 using an alternate in-frame splice site in one exon compared to variant 1 lacking another in-frame exon compared to variant 1 NM_001017958 15 splicing 2824 NP_001017958 - 652 - Kimura, Bernasconi (2008) using an alternate in-frame splice site in the 3' coding region compared to variant 1

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       moderately Lymphoid/Immune spleen       moderately   thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular

cell lineage
cell lines	from an osteosarcoma-cell line
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved mannose 6-phosphate receptor homology (MRH) domains, binding to N-glycans lacking the C branch terminal mannose residues
	lectin domain required to enhance the degradation of misfolded glycoproteins (Hosokawa 2009)

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to rattus Os-9

Homologene

FAMILY

OS-9 family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	soluble fraction

basic FUNCTION	may playing a role in cell viability
	may playing a role in the ER-associated degradation of misfolded glycoproteins
	plays a role as an auxiliary ER protein for select classes of membrane cargo proteins
	having a lectin activity required for glycoprotein ERAD (Hosokawa 2009)
	critically involved in the modulation of ER-to-Golgi transport of TM7SF4 in response to TLR triggering, suggesting a novel role for OS9 in myeloid differentiation and cell fusion (Jansen 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to the hypoxia-inducible factor 1 (HIF-1)
	interacting with TRPV4 (TRPV4-binding protein)
	interacting with SEL1L via its conserved mannose 6-phosphate receptor homology (MRH) domains
	associated with HSP90B1
	physically interacts with TM7SF4 (both proteins colocalize in the endoplasmic reticulum in various cell lines, including immature dendritic cells) (Jansen 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in osteosarcomas tumoral   amplification     coamplified with CDK4, PRIM1, SAS in osteosarcoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS