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FLASH GENE
Symbol ORC6 contributors: mct - updated : 20-12-2014
HGNC name origin recognition complex subunit 6
HGNC id 17151
Corresponding disease
MGORS3 Meier-Gorlin syndrome 3
Location 16q11.2      Physical location : -
Synonym name origin recognition complex, subunit 6 homolog-like (yeast)
Synonym symbol(s) ORC6L
DNA
TYPE functioning gene
STRUCTURE 8.75 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1647 28.1 252 - 2002 12169736
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • middle domain, including AAs 94–187, has an overall fold similar to the corresponding helical domain of transcription factor TFIIB
    • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to Drosophila Orc6p
    Homologene
    FAMILY
  • ORC6 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes in the nucleus together with other ORC subunits and also associates with chromatin
    • basic FUNCTION
  • coordinating chromosome replication and segregation with cytokinesis
  • implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function
  • necessary during mitosis for the abscission stage of cytokinesis
  • may participate in positioning of ORC at the origins of DNA replication similar to the role of TFIIB in positioning transcription preinitiation complex at the promoter
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the six subunits of the origin recognition complex
  • essential component for replication initiation, although its functions vary in different eukaryotic species
    • INTERACTION
    DNA binding to autonomously replication sequence (ARS) consensus sequence (ACS)
    RNA
    small molecule
    protein
  • interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
  • connection between ORCs and chromatin structure via the Set1 complex
  • ORC6 not only interacts with ORC1-ORC5 but also with the initiation factor CDC6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MGORS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    depletion during mitosis suffices to cause asymmetric division and failure in cytokinesis, with a delay in daughter cell abscission
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    may be a potential novel target for future anti cancer therapeutic development in colon cancer
    ANIMAL & CELL MODELS