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FLASH GENE
Symbol ORC5 contributors: mct/ - updated : 15-05-2019
HGNC name origin recognition complex, subunit 5
HGNC id 8491
Location 7q22.1      Physical location : -
Synonym name
  • origin recognition complex, subunit 5-like (yeast)
  • protein phosphatase 1, regulatory subunit 117
  • Synonym symbol(s) ORC5L, Orc5p, ORC5T, ORC5LP, PPP1R117
    DNA
    TYPE functioning gene
    STRUCTURE 81.68 kb     14 Exon(s)
    MAPPING cloned Y linked N status confirmed
    regionally located in a segment commonly deleted in myeloid malignancies
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1334 - 324 - 2016 26644179
    also called ORC5LT
    14 - 1924 - 435 - 2016 26644179
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to yeast (origin of replication recognition complex,subunit ) ORC5-like
    homolog to murine Orc5
    homolog to C.elegans zc168.3
    Homologene
    FAMILY
  • ORC family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • ORC1, ORC3, and ORC5 all localize between the chromosomes at anaphase II, but could not be detected in zygotic G1
  • basic FUNCTION
  • regulator of the initiation of DNA replication and transcription (silencing)
  • implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function
  • conserved role of ORC5 in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the six subunits of the origin recognition complex
  • INTERACTION
    DNA binding to autonomously replication sequence (ARS) consensus sequence (ACS)
    RNA
    small molecule
    protein
  • ORC2, ORC3, ORC4
  • interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
  • connection between ORCs and chromatin structure via the Set1 complex
  • ORC6 not only interacts with ORC1-ORC5 but also with the initiation factor CDC6
  • ORC5 associates with the H3 histone acetyl transferase KAT2A, and this association enhances the chromatin-opening function of ORC5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene for myeloid disorders
    Marker
    Therapy target
    ANIMAL & CELL MODELS