Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ORC5

contributors: mct/ - updated : 15-01-2004

HGNC name	origin recognition complex, subunit 5
HGNC id	8491

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q22.2      Physical location : -
Synonym name	origin recognition complex, subunit 5-like (yeast)
Synonym symbol(s)	ORC5L, Orc5p, ORC5T

DNA

TYPE	functioning gene
STRUCTURE	81.68 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in a segment commonly deleted in myeloid malignancies

RNA

TRANSCRIPTS	type	messenger

text	alternative splicing

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_181747 9 - 1310 NP_859531 - 324 - - also called ORC5LT NM_002553 14 - 1968 NP_002544 - 435 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive intestine large intestine colon   highly Reproductive female system ovary     highly   male system testis     highly   male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial barrier/lining uroepithelium     Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , complex

HOMOLOGY

interspecies	homolog to yeast (origin of replication recognition complex,subunit ) ORC5-like
	homolog to murine Orc5
	homolog to C.elegans zc168.3

Homologene

FAMILY

ORC family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	regulator of the initiation of DNA replication and transcription (silencing)
	implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function

CELLULAR PROCESS	nucleotide, replication
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

one of the six subunits of the origin recognition complex

INTERACTION

DNA	binding to autonomously replication sequence (ARS) consensus sequence (ACS)

RNA

small molecule

protein	ORC2, ORC3, ORC4
	interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
	connection between ORCs and chromatin structure via the Set1 complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene for myeloid disorders
Marker
Therapy target

ANIMAL & CELL MODELS