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FLASH GENE
Symbol ORC4 contributors: mct/ - updated : 05-04-2015
HGNC name origin recognition complex, subunit 4
HGNC id 8490
Corresponding disease
EPSS ear, patella, short stature
Location 2q23.1      Physical location : -
Synonym name
  • origin recognition complex subunit 4
  • origin recognition complex, subunit 4-like (yeast)
    • Synonym symbol(s) ORC4L, HSORC4, ORC4P, FLJ46668
    DNA
    TYPE functioning gene
    STRUCTURE 87.42 kb     15 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 6703 50.2 436 - 1998 9691185
    lacking a segment in the 5' UTR compared to variant 2
    14 - 6594 50.2 436 - 1998 9691185
    differing in the 5' UTR compared to variants 1 and 3
    14 splicing 6598 50.2 436 - 1998 9691185
    differing in the 5' UTR compared to variant 2
    15 - 6710 - 436 - 1998 9691185
    13 - 6472 - 362 - 1998 9691185
    11 - 6328 - 352 - 1998 9691185
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     pharynx   highly
    Endocrineadrenal gland   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunethymus   moderately
    Nervousbrain   highly
     nerve   highly
    Reproductivefemale systemuterus  moderately
     male systemtestis  moderately
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to rattus Orc4l (89.4 pc)
    homolog to murine Orc4l (89.6 pc)
    Homologene
    FAMILY
  • ORC4 family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a regulator of the initiation of DNA replication and transcription
  • playing a role in both chromosomal replication and mating type transcriptional silencing
  • stimulated formation of inter- and intramolecular T.A.T triplexes and created novel structures, such as homoadenine duplexes
  • unexpected potential role for ORC4 in polar body formation
  • ORC4 may likely help identify the chromosomes that are destined to be expelled in the polar body, and may play a role in polar body extrusion
  • conserved role of ORC5 in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes
    • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the six subunits of the origin recognition complex (ORC)
    • INTERACTION
    DNA binding to autonomously replication sequence (ARS) consensus sequence (ACS) in an ATP-dependent manner
  • binding to origins of replication
    • RNA
    small molecule nucleotide,
  • ATP
    • protein
  • ORC2, ORC5, ORC3
  • interacting with DBF4
  • interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EPSS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • A286V mutation, might represent a favorable prognostic marker in B-cell lymphoproliferative disorders
    • Therapy target
    ANIMAL & CELL MODELS