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FLASH GENE
Symbol ORC3 contributors: mct - updated : 15-05-2019
HGNC name origin recognition complex, subunit 3
HGNC id 8489
Location 6q15      Physical location : -
Synonym name
  • origin recognition complex, subunit 3-like (yeast)
  • origin recognition complex subunit Latheo
  • Synonym symbol(s) LAT, ORC3L, LATHEO, IMAGE50150
    DNA
    TYPE functioning gene
    STRUCTURE 77.32 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2488 - 568 - -
    20 - 2589 - 712 - -
    20 - 2586 - 711 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear localization signal (NLS)
  • helix-loop-helix (HLH) motif
  • a conserved MIR domain (PXVHH) for interaction with CBX5
  • a coiled-coil domain and a mod-interacting region (MIR) domain, can independently bind to CBX5
  • multiple CBX5-interacting domains
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Orc3
    homolog to C.elegans y119d3b.p
    homolog to yeast S.cerevisiae orc3
    homolog to Drosophila melanogaster LATHEO
    Homologene
    FAMILY ORC family
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • gradually are displaced from chromatin during S phase, ending up exclusively at centric (and in some cells, also telomeric) heterochromatin in mitosis
  • ORC1, ORC3, and ORC5 all localize between the chromosomes at anaphase II, but could not be detected in zygotic G1
  • basic FUNCTION
  • involved in transcription regulation
  • implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function
  • with ORC2 and CBX5, may be recruited to the chromatin as a single complex and require each other for their stable association to heterochromatin
  • involvement of ORC1, ORC2, ORC3 in the maintenance of constitutive heterochromatin
  • together with CBX proteins may be involved in organizing higher-order chromatin structure and centromere function
  • conserved role of ORC5 in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component one of the six components of the origin recognition complex
    INTERACTION
    DNA binding to the autonomoulsy replication sequence (ARS) consensus sequence (ACS)
    RNA
    small molecule
    protein
  • ORC2
  • ORC4
  • ORC5
  • CCNE2
  • interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
  • connection between ORCs and chromatin structure via the Set1 complex
  • interactions between ORC3 and CBX5 involve a conserved MIR domain (PXVHH) that is also found in other CBX-interacting proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS