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FLASH GENE
Symbol ORC1 contributors: mct - updated : 04-05-2009
HGNC name origin recognition complex, subunit 1-like (yeast)
HGNC id 8487
Corresponding disease
MGORS1 Meier-Gorlin syndrome 1
Location 1p32      Physical location : -
Synonym name
  • origin recognition complex, subunit 1, S. cerevisiae, homolog-like
  • origin recognition complex 1
  • replication control protein 1
  • Synonym symbol(s) MSORC1, HSORC1, ORC1L, PARC1
    DNA
    TYPE functioning gene
    STRUCTURE 31.64 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3192 97.2 861 - 1996 8884289
    17 - 3189 - 861 - -
    17 - 3177 - 856 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple CBX5-interacting domains
  • HOMOLOGY
    interspecies homolog to murine Orc1l (68.5pc)
    homolog to rattus Orc1l (70.5pc)
    Homologene
    FAMILY
  • ORC1 family (cdc6:cdc18 family)
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • only associated with heterochromatin in G1 phase before it is degraded
  • basic FUNCTION
  • regulator of the initiation of DNA replication and transcription
  • preventing cyclin E-dependent reduplication of both centrioles and centrosomes in a single cell division cycle
  • regulating the status of the ORC complex in nuclei by tethering ORCs 2-5 to nuclear structures
  • involvement of ORC1, ORC2, ORC3 in the maintenance of constitutive heterochromatin
  • together with CBX proteins may be involved in organizing higher-order chromatin structure and centromere function
  • regulates centrosome duplication
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the six subunits of the origin recognition complex
  • INTERACTION
    DNA binding to autonomously replication sequence (ARS) consensus sequence (ACS)
    RNA
    small molecule
    protein
  • interacting with MYST histone acetyltransferase 2
  • interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
  • interacting with TRF2 to achieve stable binding in prereplication complex assembly at telomeres
  • LRWD1-mediated association of ORC1, ORC2 to chromatin is critical to initiate preRC assembly in G1 and chromatin organization in post-G1 cells
  • cell & other
    REGULATION
    induced by cell growth stimulation,activation required G1 cyclin-dependent kinase activity
    Other selectively phosphorylated during mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s) MGORS1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS