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FLASH GENE

Symbol

ORC1

contributors: mct - updated : 04-05-2009

HGNC name	origin recognition complex, subunit 1-like (yeast)
HGNC id	8487

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MGORS1 Meier-Gorlin syndrome 1
Location	1p32      Physical location : -
Synonym name	origin recognition complex, subunit 1, S. cerevisiae, homolog-like
	origin recognition complex 1
	replication control protein 1
Synonym symbol(s)	MSORC1, HSORC1, ORC1L, PARC1

DNA

TYPE	functioning gene
STRUCTURE	31.64 kb     17 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004153 17 - 3192 NP_004144 97.2 861 - 1996 8884289 NM_001190818 17 - 3189 NP_001177747 - 861 - - NM_001190819 17 - 3177 NP_001177748 - 856 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

cell cycle

cell cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

multiple CBX5-interacting domains

HOMOLOGY

interspecies	homolog to murine Orc1l (68.5pc)
	homolog to rattus Orc1l (70.5pc)

Homologene

FAMILY

ORC1 family (cdc6:cdc18 family)

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome,heterochromosome
text	only associated with heterochromatin in G1 phase before it is degraded

basic FUNCTION	regulator of the initiation of DNA replication and transcription
	preventing cyclin E-dependent reduplication of both centrioles and centrosomes in a single cell division cycle
	regulating the status of the ORC complex in nuclei by tethering ORCs 2-5 to nuclear structures
	involvement of ORC1, ORC2, ORC3 in the maintenance of constitutive heterochromatin
	together with CBX proteins may be involved in organizing higher-order chromatin structure and centromere function
	regulates centrosome duplication

CELLULAR PROCESS	nucleotide, replication
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

one of the six subunits of the origin recognition complex

INTERACTION

DNA	binding to autonomously replication sequence (ARS) consensus sequence (ACS)

RNA

small molecule

protein	interacting with MYST histone acetyltransferase 2
	interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
	interacting with TRF2 to achieve stable binding in prereplication complex assembly at telomeres

cell & other

REGULATION

induced by

cell growth stimulation,activation required G1 cyclin-dependent kinase activity

Other

selectively phosphorylated during mitosis

ASSOCIATED DISORDERS

corresponding disease(s)

MGORS1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS