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FLASH GENE
Symbol ORAI2 contributors: mct/npt - updated : 25-11-2009
HGNC name ORAI calcium release-activated calcium modulator 2
HGNC id 21667
Location 7q22.1      Physical location : 102.073.995 - 102.097.268
Synonym name
  • chromosome 7 open reading frame 19
  • CAP-binding protein complex interacting protein 2
  • protein orai-2
  • transmembrane protein 142B
  • Synonym symbol(s) CBCIP2, FLJ12474, FLJ14733, C7orf19, TMEM142B, H_NH0514P08.8, FLJ44818
    DNA
    TYPE functioning gene
    STRUCTURE 23.27 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 10660 28 254 - Lee (2009)
    4 - 10769 - 254 - Lee (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion blodd
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytoplasmic C terminus required for its interaction with STIM1, and with three conserved glutamate mediating Ca(2+)-dependent inactivation (Lee 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • Orai family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in store-operated Ca(2+) entry (SOCE) with STIM1 and STIM2, ORAI1 and ORAI3 (Várnai 2009)
  • plasma membrane Ca(2+) channel that migrate and become tethered by STIM within the ER-PM junctions, where they mediate exceedingly selective Ca(2+) entry (Deng 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dynamic interplay between 2 membrane proteins, STIM1 and 2 and ORAI1 to 3, underlies an intricate coupling between Ca2+ release from endoplasmic reticulum (ER) stores and Ca2+ entry across the plasma membrane (Wang 2009)
  • cell & other
    REGULATION
    inhibited by by extracellular Ca(2+) (DeHaven 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS