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FLASH GENE
Symbol OPRL1 contributors: mct - updated : 27-08-2019
HGNC name opiate receptor-like 1
HGNC id 8155
Location 20q13.33      Physical location : 62.711.487 - 62.731.991
Synonym name
  • nociceptin receptor
  • Nociceptin/Orphanin FQ Opioid Receptor
  • orphanin FQ receptor
  • kappa-type 3 opioid receptor
  • kappa3-related opioid receptor
  • Synonym symbol(s) OOR, ORL1, KOR-3, NOCIR, MGC34578, NOPr, NOP
    DNA
    TYPE functioning gene
    STRUCTURE 20.56 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 3402 40 370 - 2000 11090272
  • transcript containing 5 exons
  • same product as variant 2
  • 5 splicing 3402 - 399 - 2000 11090272
  • transcript containing 4 exons
  • lacking of exons 2
  • same product as variant 1
  • 4 - 3251 - 370 - 2000 11090272
    6 - 3376 - 370 - 2000 11090272
    3 - 2990 - 365 - 2000 11090272
    3 - 3033 - 341 - 2000 11090272
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane receptors
  • serine 363 is a crucial C-terminal residue involved in the functional regulation of OPRL1
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Oprl (94.01 pc)
    homolog to murine Oprl (94.55 pc)
    Homologene
    FAMILY opioid receptor family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multipass membrane protein
  • basic FUNCTION
  • modulating a number or brain function
  • receptor for the neuropeptide nociceptin/orphanin FQ
  • contribution of OPRL1 in controlling food intake and meal pattern, as well as glutamate release and GIRK1 channel activity at POMC synapses
  • using both G(oA) and G(oB) for signal transduction
  • exert a modulatory effect on immune cells during sepsis
  • Nociceptin/orphanin FQ (N/OFQ) and its receptor OPRL1 have structural homology with classic opioids, but constitute a distinct neurotransmitter system because they lack affinity for the opioid peptides and receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component mediated by G proteins which inhibits adenylyl cyclase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARR3 is required for OPRL1 activation of JNK signaling
  • cell & other
    REGULATION
    Other OPRL1 function may be regulated by ADRBK2 phosphorylation of Ser-363 and ARR3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    by significantly elevated promoter methylation levels in Alzheimer disease (AD)
    constitutional     --low  
    in the brain of human alcoholic
    Susceptibility to develop opiate addiction
    Variant & Polymorphism SNP
  • association of two variants of the OPRL1 gene, rs6090041 and rs6090043, with vulnerability to develop opiate addiction
  • Candidate gene
    Marker
  • OPRL1 may be used as potential methylation biomarkers for the diagnosis of AD
  • Therapy target
    ANIMAL & CELL MODELS