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FLASH GENE

Symbol

OPRD1

contributors: mct - updated : 12-10-2011

HGNC name	opioid receptor, delta 1
HGNC id	8153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p35.3      Physical location : 29.138.653 - 29.190.208
Synonym symbol(s)	OPRD, DOR

DNA

TYPE	functioning gene
STRUCTURE	51.55 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000911 3 - 1774 - 372 - 1994 7808419

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon epithalamus pineal gland     ganglia sensory ganglia dorsal root   highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, perinatal

Text	enhanced OPRD1 expression parallel to the maturation of cardiac parasympathetic, sympathetic, and sensory innervation of the heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	depressing cAMP levels, opening a G protein-modulated K+ channel, regulating G protein expression in pineal gland
	OPRM1 is more dependent on cholesterol for efficient signaling than OPRD1 which can be partly explained by localization of OPRM- but not OPRD receptors in cholesterol- and caveolin-enriched membrane domains
	expression of OPRD1 results in reduction of endogenous ATP1A1 activity
	both OPRD1 and OPRM1 agonists reduce depolarization-induced Ca(2+) currents in single small dorsal root ganglia neurons and inhibit afferent C-fiber synaptic transmission in the dorsal spinal cord

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

form heteromers with OPRM1 and negatively regulate OPRM1-mediated spinal analgesia

INTERACTION

DNA

RNA

small molecule

protein	interacting with RGS4 (role for endogenous RGS4 protein in modulating OPRD1 signaling in SH-SY5Y cells and provide evidence for a receptor-specific effect of RGS4)
	interacting with RGS4 (acts as a GTPase accelerating protein to modulate OPRM1 and OPRD1 signaling)
	interacting with ARL6IP5 (required for maintaining the stability of OPRD1 via the ubiquitin-proteasome pathway)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS