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FLASH GENE

Symbol

OPN5

contributors: mct - updated : 12-06-2012

HGNC name	opsin 5
HGNC id	19992

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p12.3      Physical location : 47.749.774 - 47.794.114
Synonym name	neuropsin
	transmembrane protein 13
	G protein-coupled receptor 136
Synonym symbol(s)	HGNC19992, PGR12, GPR136, TMEM13, dJ402H5.1

DNA

TYPE	functioning gene
STRUCTURE	44.34 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_181744 7 - 3496 NP_859528 - 354 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain           spinal cord         Reproductive male system testis       Visual eye retina       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual Muller cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane receptor

HOMOLOGY

interspecies

homolog to murine Opn5

Homologene

FAMILY	rhodopsin family
	g-protein coupled receptors
	opsin subfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein

basic FUNCTION	rhodopsin-like receptor activity
	first and hitherto unknown human opsin with peak sensitivity in the UV region
	potentially triggers a UV-sensitive Gi-mediated signaling pathway in the mammalian tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

capable of activating heterotrimeric G protein Gi in a UV-dependent manner

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS