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FLASH GENE
Symbol OPN3 contributors: mct - updated : 12-06-2012
HGNC name opsin 3 (encephalopsin, panopsin)
HGNC id 14007
Location 1q43      Physical location : 241.756.452 - 241.803.701
Synonym name
  • panopsin
  • encephalopsin
  • Synonym symbol(s) HGNC14007, ERO, ECPN, NMO1, PANOPSIN
    DNA
    TYPE functioning gene
    STRUCTURE 47.25 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - CHML - OPN3 - KMO - qter
    Authors Halford (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - polyA site 2110 - 403 brain, retina, liver Blackshaw
    4 polyA site 2632 - 402 brain, retina, liver Blackshaw
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    VisualMuller cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane receptor domain
  • a single polypeptide chain of 340 to 500 amino acids that form 7
  • alpha-helical transmembrane regions connected by cytoplasmic and extracellular loops
  • HOMOLOGY
    Homologene
    FAMILY
  • rhodopsin family
  • superfamily of guanine nucleotide-binding protein (G protein)-coupled receptors
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be involved in phototransduction, G-protein coupled receptor protein signaling pathway
  • may be playing a role in non-visual photic processes such as the entrainment of circadian rhythm or the regulation of pineal melatonin production
  • asthma susceptibility gene on 1qter, which unexpectedly may play a role in immune modulation
  • acting as a photosensitive opsin with a functional role relating to circadian entrainment, it may play a further as yet undefined role in T-cell signaling processes and immunomodulation
  • possible role for OPN3 in modulation of T-cell responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS