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FLASH GENE
Symbol OMG contributors: mct - updated : 09-03-2011
HGNC name oligodendrocyte myelin glycoprotein
HGNC id 8135
Location 17q11.2      Physical location : 29.621.668 - 29.624.380
Synonym name GPI-anchored CNS myelin protein
Synonym symbol(s) OMGP
DNA
TYPE functioning gene
SPECIAL FEATURE
text embedded in NF1 first intron in opposite orientation
STRUCTURE 2.71 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC116236 17q11.2 hypothetical protein LOC116236 LOC90313 17q11.2 hypothetical protein BC004507 GIT1 17p11.2 G protein-coupled receptor kinase-interactor 1 FLJ25555 17q11.2 hypothetical protein FLJ25555 FLJ14871 17q11.2 hypothetical protein FLJ14871 SSH2 17q11.2 slingshot 2 FLJ46247 17q11.2 FLJ46247 protein DKFZP434K1421 17q11.2 hypothetical protein DKFZp434K1421 SLC6A4 17q11.2 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 BLMH 17q11.2 bleomycin hydrolase LOC388364 17 similar to AWKS9372 CPD 17q11.2 carboxypeptidase D GOSR1 17q11.2 golgi SNAP receptor complex member 1 LOC390784 17 similar to Arachidonate 12-lipoxygenase, 12S-type (12-LOX) (Platelet-type lipoxygenase 12) LOC388365 17 LOC388365 DKFZP434O047 17q11.2 DKFZP434O047 protein LOC284089 17q11.2 similar to keratin 17 LOC388366 17 LOC388366 DKFZp667M2411 17q11.2 hypothetical protein DKFZp667M2411 LOC388367 17 similar to Joined to JAZF1 CRLF3 17q11.2 cytokine receptor-like factor 3 FLJ12735 17q11.2 cytokine receptor-like factor 3 FLJ22729  hypothetical protein FLJ22729 CENTA2 17q11.2 centaurin, alpha 2 RNF135 17q11.2 ring finger protein 135 NF1 17q11.2 neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) OMG 17q11.2 oligodendrocyte myelin glycoprotein EVI2B 17q11.2 ecotropic viral integration site 2B EVI2A 17q11.2 ecotropic viral integration site 2A AK3P1 17q11.2 adenylate kinase 3 pseudogene 1 RAB11-FIP4  rab11-family interacting protein 4 LOC339281 17q11.2 hypothetical LOC339281 HSA272196 17q11.2 hypothetical protein, clone 2746033 HCA66 17q11.2 hepatocellular carcinoma-associated antigen 66 JJAZ1 17q11.2 hepatocellular carcinoma-associated antigen 66 LOC114659  KIAA0563-related gene LOC390785 17 hypothetical gene supported by NM_019613 ARHT1 17q11.2-q12 ras homolog gene family, member T1 RHBDL4 17q11.2 rhomboid, veinlet-like 4 (Drosophila) NJMU-R1 17q12 protein kinase Njmu-R1 ZNF207 17q11.2 zinc finger protein 207 PSMD11 17q12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 CDK5R1 17p11.2-q11 cyclin-dependent kinase 5, regulatory subunit 1 (p35) MYO1D 19p13.3-p13.2 myosin ID DKFZP564K1964 17q12 DKFZP564K1964 protein SPACA3 17q12 sperm acrosome associated 3 ACCN1 17q11.2-q12 amiloride-sensitive cation channel 1, neuronal (degenerin)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1945 - 440 - 2003 12716421
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralwhite matter  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight leucine-rich repeats
  • five Ser/Thr-rich repeats
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Omg
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to the interactive process required for myelination in central nervous system
  • inhibiting neurite outgrowth and axonal regeneration after brain injury
  • implicated in growth cone collapse and neurite outgrowth inhibition by signaling through the RTN4R and paired Ig-like receptor B (LILRB3)
  • physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to RTN4R
  • NOGO receptor ligand
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS