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FLASH GENE
Symbol OLIG1 contributors: mct/shn - updated : 21-10-2010
HGNC name oligodendrocyte transcription factor 1
HGNC id 16983
Location 21q22.11      Physical location : 34.442.449 - 34.444.727
Synonym name
  • basic domain, helix-loop-helix protein, class B, 6
  • class B basic helix-loop-helix protein 6
  • class E basic helix-loop-helix protein 21
  • oligo1; oligodendrocyte lineage transcription factor 1
  • oligodendrocyte-specific bHLH transcription factor 1
  • Synonym symbol(s) BHLHB6, BHLHE21
    DNA
    TYPE functioning gene
    STRUCTURE 2.28 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D21S261 - D21S262 - OLIG1 - D21S1898 - D21S1910 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2293 - 271 - 2000 10719889
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    cell lineage expressed exclusively in oligodendrocytes and oligodendrocyte progenitors
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic helix-loop-helix (HLH) domain
  • HOMOLOGY
    interspecies ortholog to Olig1, Mus musculus
    ortholog to Olig1, Rattus norvegicus
    ortholog to olig1, Danio rerio
    ortholog to OLIG1, Pan troglodytes
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text specifically expressed in zones of neuroepithelium in the oligodendrocyte precursors
    basic FUNCTION
  • promoting formation of a chondroitin sulfate proteoglycan-positive glial progenitor
  • has roles in development and maturation of oligodendrocytes
  • requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis
  • controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells
  • important for differentiation of oligodendrocyte precursors into myelin-forming oligodendrocytes during development and is thought to play a crucial role in remyelination during multiple sclerosis (Li 2007)
  • transcription factor that is essential for oligodendrogenesis, but is not actively required in differentiated oligodendrocytes (Gong 2008)
  • promotes oligodendrocyte maturation and is required for myelin repair (Chen 2009)
  • play a role in ventral telencephalic neurogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of GPR17
  • associates physically with another myelin-associated transcription factor, SOX10, and the OLIG1/SOX10 complex activates MBP(myelin basic protein) transcription via conserved DNA sequence motifs in theMBP promoter region
  • stage-specific regulatory role for OLIG2, mediated by OLIG1 that conveys opposing functions on the differentiation and maturation of oligodendrocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oligodendroglial tumors and anaplastic astrocytomas
    constitutional   amplification    
    Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
    Susceptibility susceptibility to multiple sclerosis
    Variant & Polymorphism
    Candidate gene OLIG1 protein expression could be utilized as a novel prognostic factor, which could aid in deciding which non-small cell lung cancer patients might benefit from more aggressive therapy
    Marker
  • a molecular marker for human glial brain tumors
  • Therapy target
    ANIMAL & CELL MODELS
  • in Olig1(-/-)2(-/-) double-mutant mice motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished
  • Olig1 is triplicated and overexpressed in the Ts65Dn mouse forebrain (mouse models of Down syndrome) displaying cognitive deficits