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FLASH GENE
Symbol OLFML2A contributors: - updated : 25-03-2006
HGNC name olfactomedin-like 2A
HGNC id 27270
Location 9q33.3      Physical location : 127.539.436 - 127.577.157
Synonym name
  • olfactomedin-like
  • photomedin-1
    • Synonym symbol(s) RP11-175D17.4, FLJ00237, PRO34319
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Hearing/Equilibriumear   highly
    Reproductivefemale systemovary  highly
    Visualeyeretina   
     eyeanterior segmentiris  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tandem CXCXCX9C motifs in the N-terminal region
  • a coiled-coil domain
  • an olfactomedin domain in the C-terminal region
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum
    basic FUNCTION
  • may participate in the obstruction of fluid outflow in the trabecular meshwork
  • olfactomedin-domain-containing extracellular proteins capable of binding to proteoglycans containing these glycosaminoglycan chains
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with OLFM3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS