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FLASH GENE
Symbol OLFM4 contributors: mct - updated : 04-07-2011
HGNC name OLFM4 olfactomedin 4
HGNC id 17190
Location 13q14.3      Physical location : 53.602.971 - 53.626.186
Synonym name
  • G-CSF stimulated clone 1
  • differentially expressed in hematopoietic lineages
  • antiapoptotic protein GW112
  • Synonym symbol(s) GC1, GW112, OlfD, bA209J19.1, KIAA4294
    DNA
    TYPE functioning gene
    STRUCTURE 23.22 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2844 57 510 - 2002 11867215
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus     Homo sapiens
     intestinelarge intestinecolon   Homo sapiens
     intestinesmall intestine    Homo sapiens
     stomach     Homo sapiens
    Reproductivefemale systemuterus  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier liningendometrium highly Homo sapiens
    Nervousperipherous   
    cell lineage myeloid lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one signal peptide
  • six N-linked glycosylation motif
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • olfactomedin-related protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a possible matrix-related function in differentiation
  • facilitates cell adhesion and its potential interaction with endogenous cell surface lectins and cadherin may mediate this function
  • involved in colon cancer adhesion and metastasis
  • exerts considerable influence on the host defense against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production
  • plays an important role in myeloid leukemia cellular functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of OLFM-4 mRNA was observed in the endometrium of endometriosis patients (
    constitutional     --over  
    in inflammatory bowel diseases and Helicobacter pylori infected patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a useful marker for tumor differentiation and progression of human colon carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    induction of OLFM4-mediated effects may contribute to the therapeutic value of ATRA (all-trans-retinoic acid)
    ANIMAL & CELL MODELS