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FLASH GENE
Symbol OIT3 contributors: mct - updated : 02-11-2022
HGNC name oncoprotein induced transcript 3
HGNC id 29953
Location 10q22.1      Physical location : 74.653.338 - 74.692.787
Synonym name
  • liver-specific ZP domain-containing protein
  • liver-specific zona pellucida domain-containing protein
  • Synonym symbol(s) FLJ39116, LZP
    DNA
    TYPE functioning gene
    STRUCTURE 39.30 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2210 - 545 - 2022 35353239
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   specific Homo sapiens
     mouthtongue   
    Lymphoid/Immunespleen    
    UrinarykidneytubuleHenles loop   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three EGF-like domains
  • a ZP domain with D8C (domain with conserved eight cysteines in liver-specific ZP domain)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nuclear envelope
    text
  • localized to the endoplasmic reticulum (ER) and Golgi apparatus
  • basic FUNCTION
  • may play a role in regulating the circulating activity of cytokines as it binds to IL1, IL2 and TNF with high affinity
  • is a new partner of Tamm-Horsfall protein on renal tubules
  • OIT3 could likely maintain urate homeostasis by regulating the excretion and reabsorption of uric acid in renal tubule via cooperating with Tamm-Horsfall glycoprotein (THP)
  • is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability
  • OIT3 is a novel biomarker of alternatively activated macrophages and facilitates Hepatocellular carcinoma (HCC) metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS