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FLASH GENE
Symbol OIP5 contributors: mct/npt - updated : 24-04-2017
HGNC name Opa interacting protein 5
HGNC id 20300
Location 15q15.1      Physical location : 41.601.467 - 41.624.819
Synonym name
  • LAP2alpha interactor-25
  • cancer/testis antigen 86
    • Synonym symbol(s) LINT-25, MIS18beta, CT86, 5730547N13Rik
    DNA
    TYPE functioning gene
    STRUCTURE 23.35 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1245 - 229 - Naetar (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cluster of basic residues
  • a cysteine motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role with TMPO during cell cycle exit, in which OIP5 acts upstream of TMPO
  • cancer-testis specific gene
  • centromeric localization of MIS18 complex is essential for the subsequent recruitment of de novo-synthesized CENPA
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MIS18A/MIS18BP1/OIP5 complex (MIS18 complex) is accumulated specifically at the telophase-G1 centromere
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • outer membrane protein OpaP from Neisseria gonorrhoeae
  • interaction partner of TMPO
  • BTRC-mediated regulation of OIP5 stability is a mechanism to restrict centromere function of OIP5 complex from late mitosis to early G1 phase
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric and testis cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS