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FLASH GENE
Symbol OIP5 contributors: mct/npt - updated : 24-04-2017
HGNC name Opa interacting protein 5
HGNC id 20300
Location 15q15.1      Physical location : 41.601.467 - 41.624.819
Synonym name
  • LAP2alpha interactor-25
  • cancer/testis antigen 86
    • Synonym symbol(s) LINT-25, MIS18beta, CT86, 5730547N13Rik
    DNA
    TYPE functioning gene
    STRUCTURE 23.35 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390578 15 similar to BLOCK 23 LOC388114 15 LOC388114 LOC388115 15 similar to RIKEN cDNA 2600011L02 LOC146071 15q14 similar to RIKEN cDNA 1810007E14; EST AA238765 DISP2 15q14 dispatched homolog 2 (Drosophila) FLJ14502 15q14 TRAF4 associated factor 1 IVD 15q14-q15 isovaleryl Coenzyme A dehydrogenase KIAA0945 D4ST-1 15q14 isovaleryl Coenzyme A dehydrogenase MGC20481 15q14 hypothetical protein MGC20481 C18B11 15q13.3 C18B11 homolog (44.9kD) AF15Q14 15q14 AF15q14 protein RAD51 15q15.1 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) FLJ10579 15q14 hypothetical protein FLJ10579 GCHFR 15q15 GTP cyclohydrolase I feedback regulatory protein FLJ10634 15q14 hypothetical protein FLJ10634 ZFYVE19 15q14 zinc finger, FYVE domain containing 19 PPP1R14D 15q13.3 protein phosphatase 1, regulatory (inhibitor) subunit 14D SPINT1 15q15 serine protease inhibitor, Kunitz type 1 ARHV 15q13.3 ras homolog gene family, member V VPS18 15q14-q15 vacuolar protein sorting protein 18 DLL4 15q14 delta-like 4 (Drosophila) MGC4504 15q14 hypothetical protein MGC4504 KIAA1259 15q14 hypothetical protein MGC4504 HCP37 15q15.1 cytochrome c, somatic pseudogene LOC388116 15 similar to RIKEN cDNA 6720467C03 MGC33637 15q14 hypothetical protein MGC33637 CHP 15q13.3 hypothetical protein MGC33637 OIP5 15q14 Opa-interacting protein 5 NUSAP1 15q14 nucleolar and spindle associated protein 1 CIA30 KIAA0252 15q14 nucleolar and spindle associated protein 1 ITPKA 15q14-q21 inositol 1,4,5-trisphosphate 3-kinase A LTK 15q15.1-q15.2 leukocyte tyrosine kinase DKFZP727M111 15q14 DKFZP727M111 protein LOC283747 15q14 similar to elongation factor SIII p15 subunit TYRO3 15q15.1-q21.1 TYRO3 protein tyrosine kinase MGA 15q15 MAX gene associated MAPKBP1 15q14 likely ortholog of mouse mitogen activated protein kinase binding proten 1 PLA2G4B 15q11.2-q21.3 phospholipase A2, group IVB (cytosolic) SPTBN5 15q21 spectrin, beta, non-erythrocytic 5 EHD4 15q11.1-q15 EH-domain containing 4 FLJ45651 15q14 FLJ45651 protein LOC388117 15 LOC388117 cPLA2delta LOC255189 15q14 hypothetical protein LOC255189 VPS39 15q14-q15 vacuolar protein sorting 39 (yeast) DKFZP564G2022 15q14 DKFZP564G2022 protein GANC 15q15.1-q15.2 glucosidase, alpha; neutral C
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1245 - 229 - Naetar (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cluster of basic residues
  • a cysteine motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role with TMPO during cell cycle exit, in which OIP5 acts upstream of TMPO
  • cancer-testis specific gene
  • centromeric localization of MIS18 complex is essential for the subsequent recruitment of de novo-synthesized CENPA
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MIS18A/MIS18BP1/OIP5 complex (MIS18 complex) is accumulated specifically at the telophase-G1 centromere
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • outer membrane protein OpaP from Neisseria gonorrhoeae
  • interaction partner of TMPO
  • BTRC-mediated regulation of OIP5 stability is a mechanism to restrict centromere function of OIP5 complex from late mitosis to early G1 phase
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric and testis cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS