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FLASH GENE

Symbol

OGN

contributors: mct - updated : 27-01-2014

HGNC name	osteoglycin (osteoinductive factor, mimecan)
HGNC id	8126

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q22.31      Physical location : 95.146.250 - 95.166.937
Genatlas name	osteoinductive factor precursor
Synonym name	mimecan
	mimecan proteoglycan
	osteoinductive factor
	corneal keratan sulfate proteoglycan
Synonym symbol(s)	MIMECAN, OIF, SLRR3A

DNA

TYPE	functioning gene
STRUCTURE	20.73 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   enhancer   silencer   metal/iron
text structure	enhancer and silencer element in the first intron (TP53 binding site and interferon stimulated response element, ISRE )
	three initiator element, an E-box,and Oct-1, metal response element

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014057 7 splicing 2786 NP_054776 - 298 - Madisen, Mehrle OGN v2 - splicing 2793 - 316 - Madisen, Mehrle NM_033014 7 - 3068 NP_148935 - 298 - Madisen, Mehrle

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel aorta     highly Mus musculus Endocrine neuroendocrine pituitary       Homo sapiens   parathyroid         Hearing/Equilibrium ear inner cochlea   highly Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Hearing / Equilibrium cochlea cell Mus musculus not specific chondrocyte Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four leucine-rich repeats flanked by cysteine-rich regions

HOMOLOGY

interspecies

homolog to murine Ogn

Homologene

FAMILY

small leucine-rich proteoglycan family,class III

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,lysosome
text	extracellular matrix

basic FUNCTION	inducing bone formation in conjunction with transforming growth factor beta (TGFB1, TGFB2)
	pituitary secretory protein, playing an important role in the regulation of cellular growth
	may be modifiing the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis
	its downregulation is a fundamental requirement for proper arteriogenesis
	important regulator of left ventricular mass through modulation of the TGF-beta pathway
	DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
	may be a crucial humoral bone anabolic factor that is produced by muscle tissues
	may be an important factor produced by muscle-derived cells and secreted into blood that exhibits bone anabolic effects
	might play an important role in bone formation by osteoblasts at the well differentiated stage

CELLULAR PROCESS

protein

PHYSIOLOGICAL PROCESS

development

text	bone formation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

OGN expressed in pituitary corticotroph cells mainly regulates ACTH secretion in the pituitary and coordinates the hypothalamo-pituitary-adrenal axis (HPAA)

cell & other

REGULATION

Other

regulated by pituitary transcription factor-1 (POU1F1) as a marker for diagnosing pituitary tumors

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   its overexpression antagonized BMP2-induced differentiation of myoblastic cells into osteoblasts

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Ogn-deficient mice, have normal hearing thresholds