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FLASH GENE
Symbol ODF4 contributors: mct - updated : 04-06-2020
HGNC name outer dense fiber of sperm tails 4
HGNC id 19056
Location 17p13.1      Physical location : 8.243.187 - 8.249.363
Synonym name
  • cancer/testis antigen 134
  • cancer/testis antigen 136
  • testis-specific protein oppo 1
    • Synonym symbol(s) OPPO1, CT134, CT136, MGC138215, MGC138219
    DNA
    TYPE functioning gene
    STRUCTURE 6.21 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU
    text structure the first intron is rich in Alu repeats
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1180 - 257 - 2012 23096689
    3 - 835 - 142 - 2012 23096689
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific SELECTED Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may have a role in spermatids
  • may play important roles in human spermatogenesis
  • is a testis-specific gene whose overexpression has been detected in chronic myeloid leukemia patients
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MAGEA3, MAGEB4, and ODF4 may be particularly useful for diagnostic and surveillance of bladder transitional cell carcinoma (TCC) in the form of a multi-biomarker panel
  • ODF4 and RHOXF2 are proposed as putative breast cancer biomarkers at the transcript level
    • Therapy target
    ANIMAL & CELL MODELS