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FLASH GENE
Symbol ODF2 contributors: mct/npt/pgu - updated : 06-10-2020
HGNC name outer dense fiber of sperm tails 2
HGNC id 8114
Location 9q34.11      Physical location : 131.218.431 - 131.263.238
Synonym name
  • cenexin 1
  • outer dense fiber of sperm tails, 84-kD
  • sperm tail structural protein
  • cancer/testis antigen 134
  • Synonym symbol(s) FLJ44866, MGC111096, MGC9034, ODF2/1, ODF2/2, ODF84
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 44.81 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2298 - 638 predominant transcript of testes 2007 18160784
    21 - 3805 - 893 not restricted to specific tissues 2009 19386263
  • also called cenexin 1
  • efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits PLK1 through a CDC2-dependent phospho-S796 motif within the extension
  • having a novel exon 3b encoding Cenexin specific amino acids
  • splice-generated C-terminal extension mediating unanticipated centrosomal events at distinct stages of the somatic cell cycle
  • 23 - 4041 - 805 - 2013 23343771
  • Cenexin 1
  • bears an unusual C-terminal extension
  • was necessary and sufficient to induce ciliogenesis, but not ODF2
  • plays a critical role in ciliogenesis through its C-terminal extension that confers a unique ability to mediate primary cilia assembly
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
    Reproductivemale systemtestis   
    Respiratorylungalveolar duct  highly Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell Homo sapiens
    Urinaryepithelial cell Homo sapiens
    cell lineage round spermatids extending to about half the principal piece of tail sperm
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two leucine zipper motifs
  • part of the C-terminal coiled-coil region that is also important in centrosomal/ciliary targeting and fiber formation presumably by supporting self-association and the formation of higher-order structures
  • HOMOLOGY
    Homologene
    FAMILY
  • ODF2 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • critical component of the mature centriole of the centrosome where it locates to the distal appendages
  • in the dense fibrillar component of the nucleolus
  • cell cycle-related functions and localization of ODF2/Cenexin in the mother centriole
  • localizes to centrosomes, to photoreceptor primary cilia, and to basal bodies of ciliated cells of the respiratory epithelium and of the kidney
  • basic FUNCTION
  • involved in sperm tail function and motility
  • critical centrosomal component whose C-terminal extension is required for proper recruitment of PLK1 and other components crucial for normal mitosis
  • major protein of the cytoskeleton of the sperm tail
  • major component of the sperm tail outer dense fibers
  • having also nucleolar function during spermatogenesis and early embryogenesis
  • may be contributing to assorted ciliopathies
  • KCNA10, ODF2, PXN specific expression patterns imply potential functional significance in the inner ear
  • function of ODF2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes
  • is necessary for the formation of the primary cilium
  • in cycling cells, ODF2 transcription is depressed but becomes up-regulated in quiescent cells
  • cenexin modulates microtubule organization and stability to mediate spindle orientation
  • ODF2 plays a central role in centrosome cohesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the filamentous structure of the sperm tail
  • component of centrosomal scaffold that preferentially associates with the appendages of the mother centrioles in somatic cells
  • major component of the sperm tail cytoskeleton and a critical component of the mature centriole of the centrosome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to ODF1 in elongating spermatids
  • TCHP binds the centrosomal proteins ODF2 and NIN, which are localized at the distal to subdistal ends of the mother centriole
  • is an interaction partner of MARK4 and ODF2 localization to the centriole partially depended on MARK4
  • PAX6 directly regulates the activity of the ODF2 gene encoding for the appendage-specific protein ODF2 with a role for the assembly of mother centriole
  • ODF2 restricts CTNNB1 accumulation at the centrosome, thus preventing premature centrosome disjunction
  • CEP128 associates with ODF2 in the hierarchical assembly of subdistal appendage (SDA) components to elicit the microtubule-organizing function
  • ODF2, a prevalent protein involved in the formation of spermatid-specific cytoskeletal structures, is a putative binding partnerof CDC42
  • CFAP58 interacts with ODF2/Cenexin and localizes in centrosome/basal body and sperm flagellum abundantly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS