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FLASH GENE
Symbol ODAM contributors: mct - updated : 22-06-2010
HGNC name odontogenic ameloblast-associated
HGNC id 26043
Location 4q13.3      Physical location : 71.062.243 - 71.070.292
Synonym name amyloid of Pindborg odontogenic tumors
Synonym symbol(s) APIN, FLJ20513
DNA
TYPE functioning gene
STRUCTURE 8.05 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1301 - 279 - 2008 18472969
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtoothdentin predominantly Homo sapiens
 mouthgingiva  highly Homo sapiens
 mouthtoothenamel highly Homo sapiens
 salivary gland   moderately Homo sapiens
Reproductivemale systemmale genital tractepididymis lowly Homo sapiens
Respiratoryrespiratory tracttrachea    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveodontoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ODAM family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus
    text
  • during the secretory stage of amelogenesis ODAM was localized to both the nucleus and cytoplasm of ameloblasts
  • basic FUNCTION
  • may predicts survival in breast cancer
  • likely involved in dental development
  • developmental antigen that has an essential role in tooth maturation and in the pathogenesis of certain odontogenic and other epithelial neoplasms
  • presence at cell-tooth interfaces suggests involvement in adhesive mechanisms active at epithelial cells of the gingiva which bind it to the tooth surface, but its presence among other epithelial tissues indicates ODAM likely possesses broader physiological roles
  • plays important roles in enamel mineralization through the regulation of matrix metalloproteinase-20 (MMP20)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with RUNX2 (RUNX2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP20 apart from a different, currently unidentified, function of extracellular ODAM)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • novel biomarker for human breast cancer
  • Marker
    Therapy target
  • may serve as a novel prognostic biomarker, as well as a potential diagnostic and therapeutic target for patients with breast and other epithelial forms of cancer
  • ANIMAL & CELL MODELS