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FLASH GENE
Symbol OBFC2A contributors: SGE/npt - updated : 18-06-2008
HGNC name oligonucleotide/oligosaccharide-binding fold containing 2A
HGNC id 26232
Location 2q32.3      Physical location : 192.542.797 - 192.553.247
Synonym name
  • CDNA: FLJ22833 fis, clone KAIA4266
  • single-stranded DNA-binding protein 2
  • Synonym symbol(s) FLJ13624, FLJ22833, MGC111163, SSB2, DKFZp667M1322
    DNA
    TYPE functioning gene
    STRUCTURE 10.45 kb     6 Exon(s)
    motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3866 22.4 204 - Richard (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • OBFC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an essential role for a wide variety of DNA metabolic processes, including DNA replication, recombination, DNA damage detection and repair
  • participating in DNA damage-response pathways (Li 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with INTS3 and C9orf80 , complex required for efficient homologous recombination (HR)-dependent repair of DNA double strand breaks and ATM-dependent signaling pathways (Li 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS