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FLASH GENE
Symbol OAZ2 contributors: mct - updated : 26-06-2012
HGNC name ornithine decarboxylase antizyme 2
HGNC id 8096
Location 15q22.31      Physical location : 64.979.772 - 64.995.462
Synonym name antizyme 2
Synonym symbol(s) ODC-Az 2
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 15.70 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
USP3 15q22.3 ubiquitin specific protease 3 LOC390593 15 similar to RIKEN cDNA 1110004B15 HERC1 15q22 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 DAPK2 15q22.1 death-associated protein kinase 2 FLJ22875 15q22.1 hypothetical protein FLJ22875 SNX1 15q22-q23 sorting nexin 1 SNX22 20q12-13.1 sorting nexin 22 PPIB 15q21-q22 peptidylprolyl isomerase B (cyclophilin B) CSNK1G1 15q22.1-q22.31 casein kinase 1, gamma 1 KIAA0101 15q22.1 casein kinase 1, gamma 1 TRIP4 15q22.1 thyroid hormone receptor interactor 4 KIAA0295 15q21.3-q22.1 thyroid hormone receptor interactor 4 OAZ2 15q22 ornithine decarboxylase antizyme 2 RBPMS2 15q22.1 RNA-binding protein with multiple splicing 2 FLJ22692 15q22.1 hypothetical protein FLJ22692 pp9099 15q22.1 PH domain-containing protein LOC348094 15q22.2 hypothetical protein LOC348094 ACP33 15q21-q22 hypothetical protein LOC348094 MtFMT 15q22.2 methionyl-tRNA formyltransferase, mitochondrial OSTbeta 15q22.2 organic solute transporter beta RIS LOC390594 15 similar to RIKEN cDNA C230080I20 gene LOC390595 15 similar to ubiquitin associated protein PDCD7 15q22.2 programmed cell death 7 CLPX 15q22.31 ClpX caseinolytic protease X homolog (E. coli) CILP 15q22 cartilage intermediate layer protein, nucleotide pyrophosphohydrolase FLJ20509 15q22.2 hypothetical protein FLJ20509 LOC390596 15 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1; cell division cycle 2-like 1; PITSLRE protein kinase alpha; p58/GTA protein kinase; galactosyltransferase associated protein kinase; CDC-related protein kinase p5 PUNC 15q22.3-q23 putative neuronal cell adhesion molecule NOPE 15q22.2 putative neuronal cell adhesion molecule DPP8 15q22 dipeptidylpeptidase 8 HSPC121 15q22.2 butyrate-induced transcript 1 DKFZP564O1664 15q22.2 hypothetical protein DKFZp564O1664 SLC24A1 15q22 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 IRLB 15q22.2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1936 - 189 - 1999 10352227
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • ornithine decarboxylase antizyme 2, negative regulator of polyamine level
  • controling the intracellular concentration of polyamines
  • catalyzing the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis
  • regulate ornithine decarboxylase (ODC), which is involved in polyamine synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its synthesis requires a polyamine-induced translation frameshift which links open reading frame 1 (ORF1) with open reading frame 2 (ORF2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with increased survival and with several favorable clinical neuroblastoma characteristics
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS